WoS İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/20.500.12573/394
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Article Citation - WoS: 2Citation - Scopus: 2Pangenome Analysis and Genome-Guided Probiotic Evaluation of Cyclic Dipeptides Producing Levilactobacillus Brevis DY55bre Strain From a Lactic Acid Fermented Shalgam to Assess Its Metabolic, Probiotic Potentials, and Cytotoxic Effects on Colorectal Cancer Cells(Springer, 2025-10-01) Yetiman, Ahmet E.; Horzum, Mehmet; Kanbur, Ertan; Cadir, Mehmet; Bahar, Dilek; Gurbuz, Serife; Akbulut, MikailThis study investigates the genetic, metabolic, and probiotic characteristics of Levilactobacillus brevis DY55bre, a strain isolated from the traditional Turkish fermented beverage, shalgam. Whole-genome sequencing revealed a circular genome of 2.485 Mb with a GC content of 45.72%, predicted 2791 genes, and multiple CRISPR-Cas systems. Pangenome analysis demonstrated an open structure, with 18.9% core genes and 103 strain-specific genes, highlighting its genetic diversity. The DY55bre exhibits heterofermentative carbohydrate metabolism due to the presence of the araBAD operon and the lack of 1-phosphofructokinase (pfK) and fructose-1,6-bisphosphate aldolase enzymes. Probiotic evaluation revealed firm survival under simulated gastrointestinal conditions, including resistance to acidic pH (as low as 3.0) and bile salts (up to 1%), along with significant adhesion to intestinal epithelial cell lines (HT29;59.3%, Caco-2;87%, and DLD-1;60.8%). The strain exhibited high auto-aggregation (84.55%) and cell surface hydrophobicity (56.69%), essential for gut colonization. Safety assessments confirmed its non-hemolytic nature and absence of horizontally acquired antibiotic resistance genes. Notably, GC-MS analysis identified bioactive cyclic dipeptides, Cyclo(D-Phe-L-Pro) and Cyclo(L-Leu-L-Pro), which demonstrated cytotoxic effects against colorectal cancer cell lines, with IC50 values of 7.71 mg/mL for HT29 and 3.19 mg/mL for DLD-1. The cell-free supernatant exhibited antimicrobial activity against pathogens, likely due to the synergistic effects of cyclic dipeptides, organic acids, and other metabolites. Antioxidant assays revealed significant ABTS+ (76.63%) and DPPH (34.25%) radical scavenging activities, while cholesterol assimilation tests showed a 27.29% reduction. These findings position the DY55bre as a promising candidate for functional foods, nutraceuticals, and therapeutic applications, warranting further in vivo validation.Conference Object Citation - WoS: 49Citation - Scopus: 54You May Not Reap What You Sow: How Employees' Moral Awareness Minimizes Ethical Leadership's Positive Impact on Workplace Deviance(Springer, 2017-08-02) Gok, Kubilay; Sumanth, John J.; Bommer, William H.; Demirtas, Ozgur; Arslan, Aykut; Eberhard, Jared; Yigit, AhmetAlthough a growing body of research has shown the positive impact of ethical leadership on workplace deviance, questions remain as to whether its benefits are consistent across all situations. In this investigation, we explore an important boundary condition of ethical leadership by exploring how employees' moral awareness may lessen the need for ethical leadership. Drawing on substitutes for leadership theory, we suggest that when individuals already possess a heightened level of moral awareness, ethical leadership's role in reducing deviant actions may be reduced. However, when individuals lack this strong moral disposition, ethical leadership may be instrumental in inspiring them to reduce their deviant actions. To enhance the external validity and generalizability of our findings, the current research used two large field samples of working professionals in both Turkey and the USA. Results suggest that ethical leadership's positive influence on workplace deviance is dependent upon the individual's moral awareness-helpful for those employees whose moral awareness is low, but not high. Thus, our investigation helps to build theory around the contingencies of ethical leadership and the specific audience for whom it may be more (or less) influential.Article Citation - WoS: 6Citation - Scopus: 7Whether and When Did Bitcoin Sentiment Matter for Investors? Before and During the COVID-19 Pandemic(Springer, 2023-12-21) Aysan, Ahmet Faruk; Mugaloglu, Erhan; Polat, Ali Yavuz; Tekin, HasanUsing a wavelet coherence approach, this study investigates the relationship between Bitcoin return and Bitcoin-specific sentiment from January 1, 2016 to June 30, 2021, covering the COVID-19 pandemic period. The results reveal that before the pandemic, sentiment positively drove prices, especially for relatively higher frequencies (2-18 weeks). During the pandemic, the relationship was still positive, but interestingly, the lead-lag relationship disappeared. Employing partial wavelet tools, we factor out the number of COVID-19 cases and deaths and the Equity Market Volatility Infectious Disease Tracker index to observe the direct relationship between a change in sentiment and return. Our results robustly reveal that, before the pandemic, sentiment had a positive effect on return. Although positive coherence still existed during the pandemic, the lead-lag relationship disappeared again. Thus, the causal relationship that states that sentiment leads to return can only be integrated into short-term trading strategies (up to six weeks frequency).Article Citation - WoS: 10Citation - Scopus: 10Triple Band Diamond-Shaped Polarization Insensitive Plasmonic Nano Emitter for Thermal Camouflage and Radiative Cooling(Springer, 2024-05-13) Sanli, Atif Kerem; Tabaru, Timucin Emre; Kilic, Veli TayfunThis study proposes the design of a novel Metal-Insulator-Metal (MIM) nano-infrared emitter that uses a unique diamond-shaped grating to achieve selective infrared absorption. Diamond-shaped nano emitter (DNE) structure exhibits four narrow resonant peaks within key absorption windows such as short-wave infrared (SWIR) mid-wave infrared (MWIR), alongside with a wide absorption band in the Non-Transmissive Infrared Range (NTIR) for thermal camouflage applications compatible with radiative cooling. Moreover, the proposed DNE is polarization insensitive as it has an in-plane symmetric design. Using the 3D Finite-Difference Time-Domain (FDTD) simulations, we demonstrate the nanoantenna's superior performance characterized by its high absorption rates and tuned effective impedance matching. As of our knowledge, the findings suggest that this is the first time that a MIM structure achieved multiple narrow resonance peaks, located in SWIR and MWIR simultaneously, with a wide absorption range in NTIR. Represented DNE stands as a significant innovation in the field of stealth technology, providing a tunable, high-efficiency solution for managing and controlling thermal emissions across diverse applications.Article Citation - WoS: 12Citation - Scopus: 11The Seismic Behaviour of RC Exterior Shear Walls Used for Strengthening of Intact and Damaged Frames(Springer, 2020-04-07) Kucukgoncu, Hurmet; Altun, FatihSeveral strengthening techniques such as steel plate bonding, external post-tensioning, steel bracing, or addition of new structural elements have been widely used to improve the seismic behaviour of structures, which suffer from earthquakes. Especially, adding infill walls and shear walls to the structures are preferred because of the added increase in lateral strength and stiffness. Nevertheless, applications of these techniques have some difficulties in terms of labour, cost, usage, and comfort for occupants. Due to these difficulties, the exterior shear wall, instead of an infill wall, is applied to strengthen structures, especially for public buildings like schools, hospitals, etc. In this study, the seismic behaviours of the exterior shear walls used to strengthen intact and damaged frames were investigated experimentally. For this purpose, reinforced concrete shear walls were positioned in parallel to the exterior sides of the damaged and the intact three-dimensional frames. Both frames were tested under cyclic loads. After the investigation, the hysteresis curve, strength envelope, stiffness degradation, and the energy dissipation capacity were obtained to reveal the seismic behaviour of the strengthening exterior shear walls. In addition to these, the differences in behaviours of the shear walls applied to damaged and intact frames were identified.Article Citation - WoS: 18Citation - Scopus: 21Synthesis of L-Cysteine Capped Silver Nanoparticles in Acidic Media at Room Temperature and Detailed Characterization(Springer, 2017-11-29) Panhwar, Sallahuddin; Hassan, Syeda Sara; Mahar, Rasool Bux; Canlier, Ali; Sirajuddin; Arain, MunazzaThis work reports a simple and one pot synthesis of water dispersible l-cysteine stabilized silver nanoparticles (l-CYS-AgNPs) in an acidic media. Silver nanoparticles were synthesized within few minutes of reaction time (< 5 min) at room temperature without needing to heat and use of any hazardous organic solvents. Prepared nanoparticles were characterized by UV-Visible spectroscopy, Fourier transform infrared spectroscopy, transmission electron microscopy, atomic force microscopy, X-ray diffraction and zeta potential analysis, respectively. Surface plasmon resonance band of AgNPs which was observed at 392 nm by UV-Visible spectroscopy indicated successful formation of l-CYS-AgNPs in acidic media. Imaging techniques showed that AgNPs possess spherical morphology and average size of 25 nm. Nanoparticles were stable for more than 2 months when stored at ambient temperature. This approach is a facile and rapid one pot synthesis which can be stored as a homogenous aqueous dispersion for more than 2 months. Being stabilized by a sulfur-containing amino acid (l-cysteine) and the synthesis carried out in a moderately acidic media (pH 5.3) are distinctive aspect of this work. These stable l-CYS-AgNPs could be used as a catalyst and sensor applications for advanced perspective against water pollution and industrial effluents.Article Structural Behavior of Geopolymer Reinforced Concrete Beams: Experimental, Numerical, and Code-Based Assessment(Springer, 2025-08-11) Ozbayrak, Ahmet; Kucukgoncu, HurmetThis study experimentally investigates the flexural performance of heat-cured low-calcium fly ash-based geopolymer concrete (GPC) beams reinforced with ribbed steel bars, focusing on the effects of reinforcement ratio, alkaline activator concentration (SS/SH), and curing regime. Fifteen full-scale beams, including twelve GPC and three OPC specimens, were tested under four-point loading to evaluate load-deflection and moment-curvature behavior. Despite a lower compressive elastic modulus, the results showed that GPC beams exhibited comparable or superior cracking and ultimate moment capacities relative to OPC beams. Increasing the reinforcement ratio enhanced load capacity but reduced ductility in both systems, with GPC beams showing more brittle post-yield behavior. Numerical models based on OPC parameters were developed in SAP2000 to compare with experimental GPC moment-curvature data, revealing good agreement in the linear range but notable differences in post-yield response. The study also examined the microstructure of failed GPC beams via SEM, XRD, and EDX analyses to correlate matrix morphology with mechanical behavior. Finally, moment capacities calculated according to ACI 318 and TS 500 provided conservative estimates, supporting the safe applicability of current design codes to heat-cured GPC beams. These findings demonstrate that GPC, when properly proportioned and cured, is a viable structural alternative to OPC for reinforced concrete members.Article Citation - WoS: 3Citation - Scopus: 3Soap Film Analogy for Anisotropically Stretched Membranes and Cable Nets(Springer, 2016-07-22) Beatini, Valentina; Royer-Carfagni, GianniAnalogical physical models are a preferred technique to intuitively grasp complex engineering problems. It is well-known that the equilibrium minimal-surface configuration of membranes under equibiaxial tension can be visually represented by the surface of a soap film under equivalent boundary conditions, but this analogy fails when the stress state is not uniform equibiaxial. We extend to this situation the analogy with soap films. The equilibrium state of an orthotropically tensioned membrane is found by geometrically stretching the shape of a soap film, in a precise manner depending upon the applied state of stress. The procedure is easily done by elaborating digital pictures. The method is mathematically justified under the kinematic hypotheses of small strains and large rotations, and further verified in a parametric design environment. It can also provide an insight into the equilibrium configuration of cable-nets, when the stresses in the warp and weft directions are considerably different. Furthermore, this visualization favors implementing transformable shapes for membranes or orthogonal cable nets, as a consequence of a modification of the ratio of the principal stress components.Article Citation - WoS: 5Citation - Scopus: 6Size Reduction Characterization of Underground Mine Tailings: A Case Study on Sandstones(Springer, 2020-06-09) Koken, EkinThe production of construction and building materials starts with reducing the size of natural, industrial, and waste materials. In addition to strength and durability considerations of natural resources recommended by various institutions, size reduction characterization, specific to rock aggregates, has a vital role in their size-related quality. In this study, various sandstones extracted from underground mines located in northwestern Turkey were investigated for size reduction characterizations. Several mineralogical, textural, and physico-mechanical properties were determined for each rock type. Crushability tests were carried out using a laboratory-scale cone crusher for different feeding size fractions, namely + 11.20 - 16.00 mm (size I), + 9.52 - 16.00 mm (size II), and + 6.30 - 16.00 mm (size III). Based on the crushability tests, crushed particles were analyzed, focusing on production yield, size, and shape properties. Each crushability test was also explored for energy consumption arising from varying rock properties of the sandstones. The laboratory test results demonstrated that the degree of rock crushability (DRC) and specific energy consumption (E-cs, kJ/kg) were associated with the Brazilian tensile strength (BTS, MPa) and apparent porosity (n(e), %) of the sandstones. The results also showed that the degree of sorting in mineral constituents, quantified as the sorting coefficient (S-c), affected the DRC. However, mineralogical features of the sandstones have no significant impact on DRC andE(cs). Variations in feeding gradation, irrespective of whether mineralogical, textural, or physico-mechanical properties, have remarkable effects on product flakiness and yields for specific size fractions. In light of the findings obtained, the present study provides knowledge on how the sandstones behave under cone crushing operations.Article Citation - WoS: 6Citation - Scopus: 6Sleep-Aware Wavelength and Bandwidth Assignment Scheme for TWDM PON(Springer, 2021-06) Butt, Rizwan Aslam; Faheem, Muhammad; Ashraf, M. Waqar; Arfeen, Asad; Memon, Kamran Ali; Khawaja, AttaullahThe energy efficiency and delay performance of PON are two inversely related phenomena. Higher sleep time of the Optical Network Units (ONUs) results in higher upstream (US) delays due to increased traffic queues during the ONU Asleep state. Although an efficient dynamic bandwidth and wavelength assignment (DWBA) scheme can decrease US delays by minimizing the bandwidth waste and improving the fairness of bandwidth distribution among the ONUs. However, the conventional DWBA schemes are not designed to work with cyclic sleep mode (CSM) and they keep on assigning bandwidth to ONUs even if the ONU is in Asleep state leading to wastage of bandwidth and degraded CSM performance. Therefore, in this work a sleep aware DWBA scheme for TWDM PON is presented to coordinate with CSM mode. It only assign bandwidth to Active ONUs during the guaranteed phase, surplus phase and excess phase allocation phases which minimizes the bandwidth waste and the bandwidth lost at the ONU end. The wavelength switching process is also improved by only considering the Active state ONUs to balance the traffic load on all the wavelengths. The simulation results support our claim as the SA-DWBA scheme on average achieves DWBA schemes due to up to 50% to 65% higher energy savings compared to other due to longer ONU Asleep times. However, the increased upstream delays of all the traffic classes in SA-DWBA scheme remain within the set delay limit of 50 ms.