WoS İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/20.500.12573/394
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Article Citation - WoS: 36Citation - Scopus: 37Histopathological and Biomechanical Evaluation of Tenocyte Seeded Allografts on Rat Achilles Tendon Regeneration(Elsevier Sci Ltd, 2015-05) Gungormus, Cansin; Kolankaya, Durdane; Aydin, ErkinTendon injuries in humans as well as in animals' veterinary medicine are problematic because tendon has poor regenerative capacity and complete regeneration of the ruptured tendon is never achieved. In the last decade there has been an increasing need of treatment methods with different approaches. The aim of the current study was to improve the regeneration process of rat Achilles tendon with tenocyte seeded decellularized tendon matrices. For this purpose, Achilles tendons were harvested, decellularized and seeded as a mixture of three consecutive passages of tenocytes at a density of 1 x 10(6) cells/ml. Specifically, cells with different passage numbers were compared with respect to growth characteristics, cellular senescence and collagen/tenocyte marker production before seeding process. The viability of reseeded tendon constructs was followed postoperatively up to 6 months in rat Achilles tendon by histopathological and biomechanical analysis. Our results suggests that tenocyte seeded decellularized tendon matrix can significantly improve the histological and biomechanical properties of tendon repair tissue without causing adverse immune reactions. To the best of our knowledge, this is the first long-term study in the literature which was accomplished to prove the use of decellularized matrix in a clinically relevant model of rat Achilles tendon and the method suggested herein might have important implications for translation into the clinic. (C) 2015 Elsevier Ltd. All rights reserved.Article Citation - WoS: 81Citation - Scopus: 91Alkali Activation of Mortars Containing Different Replacement Levels of Ground Granulated Blast Furnace Slag(Elsevier Sci Ltd, 2012-03) Bilim, Cahit; Atis, Cengiz Duran; Ati, Cengiz DuranThe aim of the present study is to investigate some properties of alkali-activated mortars containing slag at different replacement levels. Ground granulated blast furnace slag was used at 0%, 20%, 40%, 60%, 80% and 100% replacement by weight of cement, and liquid sodium silicate having three different Na dosages was chosen as the alkaline activator. In this research, carbonation resistance measurements and compressive and flexural strength tests were performed on the mortar specimens with size of 40 x 40 x 160 mm. The findings obtained from the tests showed that carbonation depth values of the mortars decreased with the increase of activator dosage. Additionally, compressive and flexural strength values increased with the increase in activator concentration and slag replacement level. Portland cement/slag mortars activated by liquid sodium silicate exhibited lower strength than the slag alone activated by the same activator. (C) 2011 Elsevier Ltd. All rights reserved.