WoS İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/20.500.12573/394
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Article Citation - Scopus: 1Correlation of PAPP-A Values With Maternal Characteristics, Biochemical and Ultrasonographic Markers of Pregnancy(Marmara Univ, Fac Medicine, 2021-01-29) Kaymakcalan, Hande; Uzut, Ommu Gulsum; Harkonen, Juho; Bakir Gungor, Burcu; Bakir-gungor, Burcu; Söylemez, Ümmü GülsümObjective: Our aim is to investigate whether there is a correlation of pregnancy-associated plasma protein A (PAPP-A) values with other variables in pregnancy and maternal characteristics. Materials and Methods: We retrospectively analyzed the relation between the PAPP-A levels, demographics, biochemical and ultrasonographic markers of the first trimester screening of 11,842 pregnant women seen at a tertiary hospital between November 2002 and November 2008. Results: A significant difference between PAPP-A values of the diabetic and non-diabetic pregnant women were observed (p=0.0005, Mann-Whitney U test). In terms of weight, crown-rump length, Beta-hCG values, significant differences were observed between low and medium level PAPP-A subgroups and between low and high level PAPP-A subgroups. PAPP-A levels were found to differ significantly between the pregnant women of Caucasian origin and other racial origins. Conclusions: Pregnant women with different ethnic and medical backgrounds have different PAPP-A values and other markers of the aneuploidy screening. 'lb make patient specific risk predictions, understanding these interactions and differences is important. Future studies are needed to understand the pathopyhsiology behind these differences.Conference Object Citation - Scopus: 1The Relationship Between PAPP-A Levels, Maternal Characteristics, Gestational Diabetes and Other Biochemical Markers of the Aneuploidy Screening(Institute of Electrical and Electronics Engineers Inc., 2018-09) Uzut, Ömmu Gülsüm; Kaymakçalan, Hande; Härkönen, Juho; Bakir-Güngör, Burcu; Celebiler, Hande KaymakcalanFirst trimester aneuploidy screening is routinely used in pregnancy follow-ups. In this screening, free β-hCG and pregnancy-associated plasma protein A (PAPP-A) levels in the blood of the pregnant woman are measured. The aim of this study is to investigate the relationship between PAPP-A levels, maternal characteristics, diabetes, ultrasound measurements of the fetus and other biochemical markers of the aneuploidy screening. In this study, we used the dataset of 12 428 pregnant women, who are followed by some of our researchers at the Prenatal Unit of Yale University Hospital in USA. The correlation of free-β-hCG, PAPP-A and Down syndrome risk with thyroid stimulating hormone (TSH), glucose and hematocrit was analyzed. A statistically significant correlation (p=0.0005) was found between the PAPP-A levels in the group of diabetic pregnants and PAPP-A levels in non-diabetic pregnant group. Detailed studies on the effect of PAPP-A on insulin growth factor could make it possible to use PAPP-A levels to predict gestational diabetes. © 2019 Elsevier B.V., All rights reserved.