WoS İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/20.500.12573/394
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Article Integrative Bioinformatics Prediction of West Nile Virus-Derived microRNAs Reveals Potential Host Regulatory Interactions(Elsevier Sci Ltd, 2026-08) Demirci, Muserref Duygu Sacar; Orhan, Mehmet Emin; Erginkoc, Altay Nida; Saçar Demirci, Müşerref DuyguWest Nile virus (WNV) is a mosquito-borne flavivirus linked to severe neuroinvasive disease. Although host and vector microRNAs (miRNAs) have been implicated in viral infection, the presence and functional relevance of WNV-encoded miRNAs remain largely unexplored. Here, we developed an integrative bioinformatics pipeline that combines multiple miRNA prediction algorithms with secondary structure screening and host transcriptomic data to identify high-confidence candidate WNV-derived mature miRNAs. Overlap-based confidence scoring and differential expression support from RNA-seq datasets prioritized a small subset of putative miRNA-mRNA interactions with potential roles in infection-associated gene regulation. A competitive endogenous RNA network constructed from predicted mRNA, lncRNA, and circRNA targets highlighted pathways involving innate immunity, GPCR and Wnt signaling, RNA degradation, and viral replication. Together, these findings provide a reproducible computational workflow and nominate testable regulatory interactions for future experimental validation.Article Citation - WoS: 1Citation - Scopus: 1Numerical Analysis and Experimental Comparison of Stress and Stiffness Parameters of Steel Reinforced Geopolymer Concrete Columns(Elsevier Sci Ltd, 2026-01) Ozbayrak, Ahmet; Kucukgoncu, Hurmet; Aslanbay, Huseyin Hilmi; Aslanbay, Yuksel Gul; Altun, FatihDespite extensive research, Geopolymer concrete (GPC) lacks reinforced concrete construction and design specifications. Developing such specifications requires comprehensive studies to promote the use of GPC, which is known for its superior performance and environmental benefits compared to ordinary Portland cement concrete (OPC). This study numerically investigated and compared the behavior and strength of fly ash-based geopolymer-reinforced concrete columns with the experimental results. Comparisons with OPC were made based on existing specifications. Herein, FEM analyses were conducted on 16 GPC and 4 OPC columns under eccentric axial compressive loads. Parameters such as eccentricity, reinforcement ratio, curing method, and activation solution ratios were varied. According to average numerical results, the GPC columns have 7% more moment capacity and 30% more curvature values than OPC. Moreover, GPC columns absorbed more energy than OPC columns. Also, GPC columns have higher axial load and bending moment carrying capacities than OPC for numerical results. Error analysis between FEM and experimental data revealed a strong correlation, with MAPE values of 8.88% (axial load) and 7.20% (moment) for GPC columns, confirming the reliability of the numerical model. ACI 318 and Eurocode 2 specifications were deemed applicable for GPC columns, provided axial loads are limited per TEC 2018.Article Citation - WoS: 38Citation - Scopus: 38pH- and Temperature-Responsive Amphiphilic Diblock Copolymers of 4-Vinylpyridine and Oligoethyleneglycol Methacrylate Synthesized by RAFT Polymerization(Elsevier Sci Ltd, 2014-01) Topuzogullari, Murat; Bulmus, Volga; Dalgakiran, Eray; Dincer, SevilDiblock copolymers of 4-vinylpyridine (4VP) and oligoethyleneglycol methyl ether methacrylate (OEGMA) were synthesized for the first time using RAFT polymerization technique as potential drug delivery systems. Effects of the number of ethylene glycol units in OEGMA, chain length of hydrophobic P4VP block, pH, concentration and temperature on the solution behavior of the copolymers were investigated comprehensively. Copolymer chains formed micelles at pH values higher than 5 whereas unimeric polymers were observed to exist below pH 5, owing to the repulsion between positively charged P4VP blocks. The size of the micelles was dependent on the relative length of blocks, P4VP and POEGMA. Thermo-responsive properties of copolymers were investigated depending on the pH and length of P4VP block. The increase in the length of P4VP block decreased the LCST substantially at pH 7. At pH 3, LCST of copolymers shifted to higher temperatures due to the increased interaction of copolymers with water through positively charged P4VP block. (C) 2013 Elsevier Ltd. All rights reserved.Article Citation - WoS: 39Citation - Scopus: 51What Are the Key Success Factors for Strategy Formulation and Implementation? Perspectives of Managers in the Hotel Industry(Elsevier Sci Ltd, 2020-08) Koseoglu, Mehmet Ali; Altin, Mehmet; Chan, Eric; Aladag, Omer FarukThis study investigates how hotel managers describe strategy and identify key success factors for its formulation and implementation. The study analyzes qualitative data collected through semi-structured interviews with property level top managers of hotels in Hong Kong. The findings show that hotel managers prioritize competition analysis and macro-environmental conditions over internal characteristics such as teamwork in strategy formulation. In the implementation phase, however, internal considerations such as employee involvement and strategic consensus are given prominence. This study provides a significant contribution by examining how top level practitioners in the industry interpret success factors in their strategic management efforts, and it highlights a largely neglected area in the hospitality and tourism management literature.Article Citation - WoS: 24Citation - Scopus: 33Variable Structure Controllers for Unstable Processes(Elsevier Sci Ltd, 2015-08) Ablay, GunyazA variable structure control (VSC) method for unstable industrial processes is proposed. The proposed control method is able to provide a highly satisfactory system performance and to tackle with robustness issues of the processes in the presence of uncertainties. An ITAE-based numerical tuning algorithm for acquiring optimal control parameters, and a direct auto-tuning mechanism for the proposed controller are also provided. The performance of the proposed VSC method is illustrated on some unstable process models including a continuous stirred tank reactor (CSTR), in order to show its effectiveness, validity and feasibility. (C) 2015 Elsevier Ltd. All rights reserved.Article Citation - WoS: 23Citation - Scopus: 28Ultra-Rapid Catalytic Degradation of 4-Nitrophenol With Ionic Liquid Recoverable and Reusable Ibuprofen Derived Silver Nanoparticles(Elsevier Sci Ltd, 2018-06) Hassan, Syeda Sara; Carlson, Krista; Mohanty, Swomitra Kumar; Sirajuddin; Canlier, AliThis study reports a one-pot and eco-friendly method for the synthesis of spherical ibuprofen derived silver nanoparticles (IBU-AgNPs) in aqueous media using ibuprofen analgesics drug as capping as well as reducing agent. Formation of AgNPs occurred within a few min (less than 5 min) at room temperature without resorting to any harsh conditions and hazardous organic solvents. Synthesized AgNPs were characterized with common analytical techniques. Transmission electron microscope (TEM) images confirmed the formation of spherical particles having a size distribution in the range of 12.5 +/- 1.5 nm. Employment of IBU analgesic aided the control of better size distribution and prevented agglomeration of particles. Such AgNPs solution was highly stable for more than two months when stored at ambient temperature. The IBU-AgNPs solution showed excellent ultra-rapid catalytic activity for the complete degradation of toxic 4-nitrophenol (4-NPh) into non-toxic 4-aminophenol (4-APh) within 40 s. AgNPs were recovered with the help of water insoluble-room temperature ionic liquid and reused with enhanced catalytic potential. This method provides a novel, rapid and economical alternative for the treatment of toxic organic pollutants to maintain water quality and environmental safety against water pollution. It is extendable for the control of other reducible contaminants in water as well. Furthermore, this catalytic activity for an effective degradation of organic toxins is expected to play a crucial role for achieving the Sustainable Development Goal 6 set by United Nations. (C) 2017 Elsevier Ltd. All rights reserved.Article Citation - WoS: 130Citation - Scopus: 157Thermal Conductivity, Compressive Strength and Ultrasonic Wave Velocity of Cementitious Composite Containing Waste PET Lightweight Aggregate (WPLA)(Elsevier Sci Ltd, 2013-02) Akcaozoglu, Semiha; Akcaozoglu, Kubilay; Atis, Cengiz DuranIn this study, the influence of waste PET as lightweight aggregate (WPLA) replacement with conventional aggregate, on thermal conductivity, unit weight and compressive strength properties of concrete composite was investigated. For this purpose, five different mixtures were prepared (the control mixtures and four WPLA mixtures including 30%, 40%, 50%, and 60% waste PET aggregate by volume). Thermal conductivity (TC) coefficients of the specimens were measured with guarded hot plate apparatus according to TS ISO 8302 [1]. The thermal conductivity coefficient, unit weight and compressive strength of specimens decreased as the amount of WPLA increased in concrete. The minimum thermal conductivity value was 0.3924 W/m K, observed at 60% WPLA replacement. From this result, it was concluded that waste PET aggregates replacement with conventional aggregate in the mixture showed better insulation properties (i.e. lower thermal coefficient). Due to the low unit weight and thermal conductivity values of WPLA composites, there is a potential of using WPLA composites in construction applications. (c) 2012 Elsevier Ltd. All rights reserved.Article Citation - WoS: 250Citation - Scopus: 280The Role of Institutional Quality and Environment-Related Technologies in Environmental Degradation for BRICS(Elsevier Sci Ltd, 2021-07) Hussain, Muzzammil; Dogan, EyupAn expanding body of literature has highlighted the environment-growth nexus. However, the literature is scarce on the role of environmental technologies and institutional quality in environmental pollution. The present study aims to contribute to the existing knowledge by utilizing environment-related technologies (ERT), institutional quality (IQ), and energy consumption to investigate ecological footprints (EF) as a proxy for the environment in BRICS economies in a framework based on environmental Kuznets curve (EKC) theory. By using data from 1992 to 2016, long-and short-term relationships are estimated through cross-section augmented autoregressive distributive lag model, augmented mean group estimator, and common correlated effects mean group. The second-generation econometric tools indicate that IQ and ERT negatively affect ecological footprints, thereby implying reductions in environmental degradation. The EKC hypothesis is not validated, implying that an increase in economic activities causes an increase in pollution. Overall, BRICS economies should improve their quality of institutions and enhance investments in environmental technologies to achieve a sustainable environment in the future. Findings are robust to practical policy implications. (c) 2021 Elsevier Ltd. All rights reserved.Article Citation - WoS: 12Citation - Scopus: 12The Role of Energy Efficiency, Renewable Resources, Green Innovation, and Fiscal Decentralization in Sustainable Development: Evidence From OECD Countries(Elsevier Sci Ltd, 2025-08) Binsaeed, Rima H.; Khan, Zeeshan; Dogan, Eyup; Rahim, SyedEnergy efficiency and renewable resources for sustainable development are novel discussion areas for academics and researchers. Similarly, most developed and emerging countries are experiencing fiscal decentralization to enhance regional development. However, the importance of these sectors in sustainable development is still unclear in the literature. This research investigates the influence of energy efficiency, renewable energy, green innovation, and fiscal decentralization on sustainable development. Using the data for 18 fiscally decentralized OECD countries from 1995 to 2020, the roles of linear and nonlinear green innovation and renewable energy are also considered. This study uses novel moment quantile regression and finds that revenue decentralization, expenditure decentralization, and fiscal decentralization are significant drivers of sustainable development. Additionally, energy efficiency and value-added manufacturing significantly enhance sustainability in the region. However, green innovation and renewables are resources that exhibit a U-shaped association with sustainable development. The robustness of these results is validated via a series of parametric and nonparametric approaches. From the policy perspective, this research suggests improved research and development on renewable energy, green innovation, and energy efficiency could significantly encourage the OECD's journey towards sustainable development. Additionally, subnational governments should be given more fiscal autonomy, which may encourage regional level investments and boost the confidence of clean energy producing sectors to accelerate sustainable regional development.Article Citation - WoS: 22Citation - Scopus: 31The Path of Least Resistance Explaining Tourist Mobility Patterns in Destination Areas Using AirBNB Data(Elsevier Sci Ltd, 2021-06) Turk, Umut; Osth, John; Kourtit, Karima; Nijkamp, PeterDestination attractiveness research has become an important research domain in leisure and tourism economics. But the mobility behaviour of visitors in relation to local public transport access in tourist places is not yet well understood. The present paper seeks to fill this research gap by studying the attractiveness profile of 25 major tourist destination places in the world by means of a 'big data' analysis of the drivers of visitors' mobility behaviour and the use of public transport in these tourist places. We introduce the principle of 'the path of least resistance' to explain and model the spatial behaviour of visitors in these 25 global destination cities. We combine a spatial hedonic price model with geoscience techniques to better understand the place-based drivers of mobility patterns of tourists. In our empirical analysis, we use an extensive and rich database combining millions of Airbnb listings originating from the Airbnb platform, and complemented with TripAdvisor platform data and OpenStreetMap data. We first estimate the effect of the quality of the Airbnb listings, the surrounding tourist amenities, and the distance to specific urban amenities on the listed Airbnb prices. In a second step of the multilevel modelling procedure, we estimate the differential impact of accessibility to public transport on the quoted Airbnb prices of the tourist accommodations. The findings confirm the validity of our conceptual framework on 'the path of least resistance' for the spatial behaviour of tourists in destination places.