WoS İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/20.500.12573/394
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Conference Object Citation - WoS: 16Citation - Scopus: 20Machine Learning Analysis of Inflammatory Bowel Disease-Associated Metagenomics Dataset(Institute of Electrical and Electronics Engineers Inc., 2018-09) Hacilar, Hilal; Nalbantoĝlu, Özkan Ufuk; Bakir-Güngör, BurcuThere is an ongoing interplay between humans and our microbial communities. The microorganisms living in our gut produce energy from our food, strengthen our immune system, break down foreign products, and release metabolites and hormones, which are significant for regulating our physiology. The shifts away from this 'healthy' gut microbiome is considered to be associated with many diseases. Inflammatory bowel diseases (IBD) including Crohn's disease and ulcerative colitis, are gut related disorders affecting the intestinal tract. Although some metagenomics studies are conducted on IBD recently, our current understanding of the precise relationships between the human gut microbiome and IBD remains limited. In this regard, the use of state-of-the art machine learning approaches became popular to address a variety of questions like early diagnosis of certain diseases using human microbiota. In this study, we investigate which subset of gut microbiota are mostly associated with IBD and if disease-associated biomarkers can be detected via applying state-of-the art machine learning algorithms and proper feature selection methods. © 2019 Elsevier B.V., All rights reserved.Conference Object Papiller Tiroid Karsinom Oluşumunda Etkili Moleküler Mekanizmaların İn Siliko Yöntemlerle Tespit Edilmesi(Institute of Electrical and Electronics Engineers Inc., 2019-04) Ersöz, Nur Sebnem; Guzel, Yasin; Bakir-Güngör, BurcuRepresenting approximately 70% to 80% of thyroid cancers, papillary thyroid cancer (PTC) is the most common type of thyroid cancers. PTC is seen in all age groups, but it is seen more frequently in women than in men. Detection of biomarker proteins of papillary thyroid cancinoma plays an important role in the diagnosis of the disease. In this study, we aim to find target genes and pathways that are associated with papillar thyroid carcinoma, by integrating different bioinformatics methods. For this purpose, usingin-silico methodologies, candidate genes and pathways that could explain disease development mechanisms are identified. Throughout this study, firstly we identified differentially expressed genes as the amount of their protein product differ between patient and healthy groups. Secondly, by using active subnetworks search algorithms, topologic analyses and functional enrichment tests, candidate proteins,which could be thought as PTC biomarkers, and affected pathways are identified. © 2020 Elsevier B.V., All rights reserved.