WoS İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/20.500.12573/394
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Article Driving Sustainability and Sustainable Developmental Goals in Hospitality: The Influence of Green HRM, Environmental CSR and Shared Green Vision on Pro-Environmental Behaviour(Wiley, 2026) Rafiq, Nosheen; Bulbul, Yagiz Efe; Cobanoglu, Cihan; Shah, Syed Haider Ali; Raza, GulzaibEnvironmental sustainability is highly dependent on the employees' pro-environmental behaviour (PEB) particularly in the hospitality industry context, yet there is still a gap of explanation on mechanisms that systematically improve employees' PEB. Based on Social Identity Theory, this study attempts to examine how green human resource management (GHRM) practices influence employees' PEB in two paths, directly and indirectly, through dual mediating mechanisms: environmental corporate social responsibility (ECSR) and green shared vision (GSV). Using a quantitative design, the study data were collected from 449 hotel managers through a structured questionnaire and analyzed with SmartPLS (SEM). The results show that GHRM has a significant positive effect on PEB and also through indirect effects of both ECSR and GSV. Further, the model explains the substantial amount of variance in PEB. The effect size reveals that indirect pathways are stronger mechanisms than the direct path from GHRM to PEB. Through bringing together the collective cognitive and identity based aspects into one framework, this study extends the theoretical understanding of mechanisms of how GHRM transform sustainability strategies into employee level environmental engagement, which is also aligned with the Sustainable Development Goals (SDGs). The study empirically broadens the GHRM research in the hospitality sector within developing country context and also presents multiple practical insights for hotel policymakers and managers to synchronize environmental strategies with employee conduct.Article Dissecting the Strain and Sex Specific Connectome Signatures of Unanesthetized C57BL/6J and DBA/2J Mice Using Magnetic Resonance Imaging(Wiley, 2026) Neuberger, Thomas; Kamens, Helen M.; Zhang, Nanyin; Ünsal, Hayreddin Said; Arefin, Tanzil M.Mouse models are an essential tool for understanding behavior and disease states in neuroscience research. While genetic and sex-specific effects have been reported in many neurodegenerative and psychiatric illnesses, these factors may also alter baseline neuroanatomical features of mice. This raises the question of whether the observed changes are related to the disease being studied (i.e., pathological differences) or if there are baseline strain or sex differences that may predispose animals to different responses. Over the past decade, tremendous effort has been made to map neural architecture at various scales; however, the complex relationships, including identifying genetic and sex-specific differences in brain structure and function, remain understudied. To bridge this gap, we used C57BL/6J and DBA/2J mice, two of the most widely used inbred mouse strains in neuroscience research, to investigate strain and sex-specific features of the brain connectome in awake animals using magnetic resonance imaging (MRI). By combining resting-state functional MRI and diffusion MRI, we found that the motor, sensory, limbic, and salience networks exhibit significant differences in both functional and structural domains between C57BL/6J and DBA/2J mice. Further, functional and structural properties of the brain were significantly correlated in both strains. Our results underscore the importance of considering these baseline differences when interpreting brain-behavior interactions in mouse models of human disorders.Article Institutions and Bank Intermediation: The Joint Role of State Capacity and Civil Liberties(Wiley, 2026) Raz, Arisyi F.; Gokmen, SeyitWe examine the effects of state capacity and civil liberties on bank intermediation, measured by banks' ability to generate liquidity in the economy. Theory suggests that a strong state that upholds civil liberties can create institutions that promote economic activity, including the development of its banking sector. We investigate this hypothesis by testing a possible channel: confidence in the banking system. Democracies tend to increase trust in the banking system by reforming institutions, while autocracies frequently rely on cronyism. Over the long run, trust in the banking system promotes banking development and intermediation in democracies, whereas cronyism and the risk of expropriation by autocrats undermine the potential for banking sector advancement in autocracies, despite having a trustworthy banking system. Our findings provide evidence in support of this channel, offering new insights into the role of political institutions in the banking sector.Article Comparison of Rapamycin and 3-Methyladenine in Cisplatin-Induced Experimental Cardiotoxicity(Wiley, 2026) Kaymak, Emin; Karabulut, Derya; Yalcin, Betul; Guner, Serife Ayaz; Ozturk, Emel; Findik, Fatma; Boyvat, DuduIn this study, we evaluated how cisplatin cardiotoxicity affects the histological and endocrine functions of the heart and autophagy while using Rapamycin(Rapa) and 3-methyladenine(3-MA) as autophagy activators and inhibitors. Control, Cisplatin (Cis), 3-methyladenine + Cisplatin (3-MA + Cis) and Rapamycin + Cisplatin (Rapa + Cis). Rapa and 3-MA were administered for 15 days, while a single dose of cisplatin was administered on the 7th day. Natriuretic peptide receptor-A(NPR-A), receptor-B(NPR-B) and biochemically atrial natriuretic peptide(ANP) and brain natriuretic peptide(BNP) levels were evaluated in heart tissue. Cis caused a statistically significant increase in NPR-A and NPR-B expression, as well as ANP and BNP levels. However, the levels of Beclin-1 and LC3B were not statistically significant. Rapa was more effective than 3-MA + Cis on NPR-A and NPR-B expressions, but did not show the same effect on ANP and NT-proBNP levels. Cis caused an increase in Beclin-1 and LC3B levels, while a decrease was observed in both 3-MA + Cis and Rapa + Cis groups. Our results revealed that Cis cardiotoxicity disrupts autophagy and endocrine function of the heart. It was concluded that by continuing the activator and inhibitor substances after Cis application, more effective results can be obtained in Beclin-1 expression than LC3B expression and that they can be effective in eliminating the toxicity of Cis.Article A Novel Dental Implant Nut System Designed to Enhance Primary Stability: Mechanical and Finite Element Analysis(Wiley, 2026) Demirbaş, Ahmet Emin; Bal, Burak; Alkan, Alper; Şahin, Mert; Soylu, EmrahPurpose: The present study aimed to evaluate, in a preclinical setting, the biomechanical behavior and mechanical performance of a newly developed dental implant nut system designed to address primary stability challenges in the severely resorbed posterior maxilla. Materials and Methods: The evaluation consisted of two complementary stages: an in vitro mechanical experiment and a finite element analysis (FEA). In the experimental phase, polyurethane jaw models simulating a severely atrophic posterior maxilla with approximately 1 mm residual bone height were used. Four groups were prepared: single implant without nut, single implant with nut, double implant without nut, and double implant with nut (n = 10 per group). Primary stability was measured using resonance frequency analysis (RFA) with an Osstell device. In the computational phase, three-dimensional finite element models were constructed from cone-beam computed tomography (CBCT) data of the same configuration to evaluate detachment forces and stress distribution within the bone-implant complex under vertical loading. Results: In single-implant models, mean implant stability quotient (ISQ) values increased from 10.91 +/- 7.35 to 18.27 +/- 7.11 after nut application. In double-implant models, ISQ values increased from 11.13 +/- 4.14 to 19.24 +/- 4.24 (p < 0.05). FEA results revealed that the detachment force increased from 16.5 to 20.33 N in single-implant models and from 15 to 22.3 N in double-implant models. Compressive stresses on the bone were lower in nut-supported configurations, indicating a more favorable load distribution. Conclusion: The nut system was associated with increased implant primary stability and a more favorable stress distribution under the conditions of this preclinical study. These findings should be interpreted as preliminary biomechanical evidence, as no in vivo or clinical validation was performed. Therefore, this design may be considered a mechanical stabilization concept that warrants further investigation through in vivo and clinical studies.Article Tooth Decay Promotes Senescence in Dental Pulp Stem Cells, Modifying Their Biological and Proteomic Profiles(Wiley, 2026) Durukan, Sebahat Melike; Tez, Banu Cicek; Ozcan, Servet; Simsek, Ahmet; Al-Sammarrie, Sura Hilal Ahmed; Gunaydin, Zeynep; Acar, Mustafa BurakDental caries is a prevalent oral health problem that significantly reduces an individual's quality of life; although, it can be effectively managed through restorative treatments. Even in cases where the caries does not reach the pulp, released microbial products from the lesion can still penetrate the pulp chamber, potentially inducing stress on pulp cells. In this study, we conducted a comparative analysis of the biological and proteomic profiles of dental pulp stem cells (DPSCs) isolated from clinically asymptomatic teeth with dentinal caries that had not reached the pulp and isolated from healthy teeth. Following biological evaluations, we examined proteomes of these DPSCs by conducting a shotgun proteomics approach. Our findings show that DPSCs from decayed teeth exhibit a significantly higher proportion of senescent cells. Proteomic profiling revealed upregulation of inflammatory signaling, extracellular matrix remodeling, and senescence-associated secretory phenotype (SASP) related proteins. Additionally, we observed an upregulation in the expression of proteins associated with extracellular matrix (ECM) remodeling and components of the SASP, which are hallmarks of the senescence process. The study reveals that DPSCs can be affected by stress from carious lesions, even when the pulp appears clinically intact. Senescence and inflammatory response in these affected cells may have deleterious effects on other tissues within the organism. Consequently, restorative treatments should consider targeting not only the decayed tissue but also the senescent cells within the pulp that may have been affected by the stress induced by caries.Article Optimizing Nanoclay-Enhanced Membranes for Oil Rejection Using Response Surface Methodology(Wiley, 2026) Gul, Ayse; Baris, Mesut; Boyraz, Pınar; Senol-Arslan, Dilek; Alibaz, Name NurThe efficient separation of waste oil from contaminated water is critical due to its challenges in environmental and industrial applications. This study investigated the production and optimization of polysulphone (PSF) membranes using two different types of clay (nanomer clay/CN and commercial nanoclay/NC). Response Surface Methodology (RSM) was applied to optimize the basic production parameters and nanoclay concentrations systematically to maximize oil rejection and permeability flow. The experimental results showed that NC and CN significantly increased the hydrophilicity, permeability, and fouling resistance of the membrane compared to pure PSF membranes. The contact angle significantly decreased from 64.34 degrees (pristine PSF) to 36.23 degrees (2% NC), indicating highly improved hydrophilicity. Consequently, the pure water flux increased from 177.2 L/m2 h to a maximum of 248.6 L/m2 h (1% NC). Furthermore, the modified membranes exhibited outstanding anti-fouling properties; the flux recovery ratio (FRR) improved from 88.09% to 96.20% (1% CN), while the decline ratio (DR) drastically dropped from 60.89% to 32.14%. The optimized condition for maximum removal efficiency using a modified quadratic model revealed that 2572 mg/L oil can be treated with a PSF membrane containing 2.0% CN to remove 98.271% of the oil. The model also suggests superiority of CN over NC with desirability factors of 0.978 and 0.900, respectively, while both demonstrated high efficiency. This theoretically modeled experimental comparative study highlights the importance of PSF membrane technology for efficient and sustainable oil-water separation and demonstrates the promising potential of nanoclay modifications.Article BrAIn: A Comprehensive Artificial Intelligence-Based Morphology Analysis System for Brain Organoids and Neuroscience(Wiley, 2026-03-12) Polatli, Elifsu; Guner, Huseyin; Bastanlar, Yalin; Karakulah, Gokhan; Evranos, Ali Eren; Kahveci, Burak; Guven, SinanHuman-induced pluripotent stem cells (iPSCs) offer transformative potential for biomedical research, with iPSC-derived organoids providing more physiologically relevant models than traditional 2D cell cultures. Among these, brain organoids (BO) are particularly valuable for drug screening, disease modeling, and investigations into molecular pathways. Accurate representation of brain morphology is critical, as more complex organoid structures better mimic the human brain. Deep learning (DL) and machine learning (ML) approaches have become integral to analyzing organoid morphology, yet tools for comprehensive, time-resolved assessments are scarce. Here, we introduce BrAIn, a DL-based application for analyzing the developmental progression of BOs. BrAIn tracks their evolution from embryoid bodies (EBs) and quantifies parameters including area, Feret diameter, perimeter, roundness, and circularity. It also classifies budding and abnormal morphologies of 3D organoids and detects monolayer neural rosette structures, key features of neuronal differentiation. Designed with accessibility in mind, BrAIn provides a no-code interface, enabling researchers of all technical backgrounds to conduct advanced morphological analyses with ease. Our study demonstrates the application of BrAIn to evaluate the effects of different growth conditions-static, orbital shaker, and microfluidic chip-based-on BO development. Orbital shaker cultures resulted in the largest organoids, while chip-based systems achieved more homogeneous growth. Both conditions produced organoids with greater morphological complexity compared to static culture. BrAIn emerges as a robust, user-friendly tool to quantify BO development and explore how versatile growth conditions influence their morphology and maturation.Article An Adaptation Mechanism of Model Reference Adaptive System Based on Variable Structure Control for Online Parameter Estimation of IPMSM(Wiley, 2026-01) Tekgun, Burak; Barut, Murat; Ates, ErtugrulThis study introduces stator currents-based model reference adaptive system (MRAS) estimators that employ variable structured control (VSC) in the adaptation mechanism to enable the online estimation of stator resistance and permanent magnet (PM) flux in interior permanent magnet synchronous motors (IPMSMs). These MRAS estimators estimate stator resistance and PM flux by analysing the error between the stator currents measured as the reference model and the stator currents generated by the adaptive model. The performance of the proposed estimators is assessed through simulation studies. Furthermore, the proposed approach is compared to a conventional MRAS employing a fixed-gain proportional-integral (PI) controller. Simulation results and error analyses indicate that the VSC-based MRAS algorithms outperform traditional PI-based MRAS in terms of accuracy and reliability. Additionally, the proposed method eliminates the reliance on a fixed-gain PI controller, a common component in conventional MRAS systems.Article Comparative Analysis of Modulation Shapes on Laser Diode Performance with a High-Efficiency LLC Resonant Converter Driver(Wiley, 2026-02-06) Yigit, Hayri; Rifat boynuegri, Ali; Tekgun, Burak; Rifat Boynuegri, AliHigh-power laser diodes (LDs) are key components in laser-based wireless power transfer (WPT) systems, where end-to-end efficiency is one of the most critical performance metrics. This study investigates the driving performance of an LD powered by a high-efficiency LLC resonant converter under three distinct excitation waveforms-sinusoidal, triangular, and rectified-sine-using a MATLAB/SIMULINK model and an experimental setup designed to reproduce real-world operating conditions. Each waveform is synthesized through frequency modulation of a full-bridge inverter stage and filtered at the output. The analysis examines the impact of modulation shape on output current ripple, converter efficiency, and overall LD efficiency. Experimental validation confirms the simulation trends, underscoring the trade-offs between waveform smoothness, implementation complexity, and efficiency. Beyond confirming that constant-current operation yields the highest LD efficiency, this study explicitly quantifies how low-frequency current ripple induced by different modulation waveforms propagates through the LLC resonant converter, alters RMS current stress, and translates into measurable efficiency degradation at both the driver and LD levels. By experimentally correlating waveform symmetry, ripple magnitude, and loss mechanisms, the work establishes practical design boundaries for waveform-modulated laser drivers in WPT systems.