WoS İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/20.500.12573/394
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Article An Elementary Proof of Lucas's Theorem(Ramanujan Mathematical Society, 2025) Cinkir, ZubeyirLucas's Theorem is about finding the result of a binomial coefficient modulo a prime p efficiently. The result is expressed as a product of binomial coefficients involving the base p expansions of the parameters of the original binomial coefficient. We give an elementary proof of Lucas's Theorem by deriving an analogous Vander-monde identity modulo a prime number.Article Analysis of Power-Law Fin-Type Problems Using Physics Informed Neural Networks(Sciendo, 2025-12-01) Gocer, M.; Coskun, S. B.; Atay, M. T.This study aims to model the temperature distribution in a single fin subjected to steady one-dimensional heat conduction with nonlinear thermal behavior. For the modeling and solution of the problem, the Physics-Informed Neural Networks (PINNs) architecture was used. The temperature-dependent heat conduction problem and the nonlinear boundary conditions of this problem were formulated with a differential equation. With the help of the PINN architecture, the loss function was minimized in order to reduce the difference between the true value and the predicted value. During this minimization process, the PINN architecture was forced to be consistent with the physical laws. The results obtained after training the PINN architecture exhibit successful performance in terms of accuracy and reliability when compared with the results in the literature. These findings highlight the potential of PINNs as a powerful alternative to conventional methods for solving complex nonlinear heat conduction problems.Article Assessment of the Quality of Tuffs in Central Anatolia, Turkey: A Quantitative Classification Approach(Acad Sci Czech Republic Inst Rock Structure & Mechanics, 2025-12-03) Koken, Ekin; Ince, IsmailThe growing global demand for dimension stones necessitates efficient and accurate evaluation methods to ensure their optimal use in various industries. To assess their suitability for various dimension stone applications, this study investigates tuffs from Central Anatolia, Turkey. For this purpose, the fundamental physical and mechanical properties of the tuffs were determined in laboratory studies, and a detailed durability assessment was conducted for each rock type. The analysis results indicate that most of the examined rocks are of low quality and more suitable for non-load-bearing applications. Based on the collected data, fuzzy clustering techniques were applied to develop a new classification system, categorising the tuffs into four classes (Class A-D) according to their potential applications. Additionally, a user-friendly MATLAB-based software tool was also developed to facilitate the implementation of the proposed classification system.Article Citation - WoS: 1Comprehensive Prediction of FBN1 Targeting Mirnas: A Systems Biology Approach for Marfan Syndrome(Galenos Publishing House, 2025-09-22) Orhan, M.E.; Demirci, Y.M.; Saçar Demirci, M.D.S.; Demirci, Muserref Duygu SacarObjective: Marfan syndrome (MFS) is a genetic connective tissue disorder primarily caused by mutations in the FBN1 gene. Emerging evidence highlights the regulatory role of microRNAs (miRNAs) in modulating gene expression in MFS, but a systematic investigation into miRNAs targeting FBN1 is lacking. This study aimed to comprehensively identify miRNAs interacting with the FBN1 transcript to reveal potential molecular regulators and therapeutic targets. Methods: Human miRNA sequences were retrieved from miRBase (Release 22.1), and the canonical FBN1 transcript (RefSeq: NM_000138.5) was used for target prediction. Computational interaction analysis was conducted using the psRNATarget server with stringent parameters to detect potential miRNA binding sites. Expression profiles and disease associations of the top candidate miRNAs were further investigated through database integration and literature review. Results: Out of 2656 human mature miRNAs analyzed, 251 were predicted to bind FBN1, with the hsa-miR-181 family exhibiting the highest number of predicted interactions. Evidence from the literature highlighted dysregulation of hsa-miR-181 expression in MFS patients, suggesting a functional role in disease pathophysiology. Conclusion: This study identifies key members of the hsa-miR-181 family as post-transcriptional regulators of FBN1, offering new insights into miRNA-driven mechanisms in MFS. These findings support the potential of RNA-based diagnostics and therapeutic strategies targeting miRNA-FBN1 interactions. ©Copyright 2025 The Author.Other Barriers in Sustainable Lean Supply Chain Management: Implementation in SMEs(Ege Univ, Fac. Economics & Admin. Sciences, 2025-02-04) Kazancoglu, Yigit; Takcı, Ebru; Ada, ErhanAs the world undergoes significant transformations in various domains, including technology, energy supply and communication, the idea of sustainability has become a significant issue. This study investigates the barriers to Sustainable Lean Supply Chain (SLSC) management within Small and Medium-Sized Enterprises (SMEs) and explores the structural interrelationships among these barriers. A comprehensive literature review was carried out to recognize critical elements relevant to the research topic, resulting in the identification of fifteen specific elements that account for 85% of the barriers in SLSC management. The DEMATEL method was used to evaluate the significance and influence levels of these factors. Furthermore, structured in-depth interviews were conducted with ten experts representing sectors that constitute 85% of the SMEs operating in Kayseri Organized Industrial Zone (OIZ), Turkey, including metal products, furniture, plastic packaging, construction materials, textiles and food. The findings reveal that strategies represent the most significant barrier to SLSC management in SMEs. The barriers were analyzed in two dimensions: influencing and influenced factors. The primary influencing factor identified was laws, standards, regulations, and legislation while the most significant influenced factor was found supply and suppliers. The study concludes with findings and actionable recommendations for practitioners and decision-makers.