WoS İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/20.500.12573/394
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Article Integrative Bioinformatics Prediction of West Nile Virus-Derived microRNAs Reveals Potential Host Regulatory Interactions(Elsevier Sci Ltd, 2026-08) Demirci, Muserref Duygu Sacar; Orhan, Mehmet Emin; Erginkoc, Altay Nida; Saçar Demirci, Müşerref DuyguWest Nile virus (WNV) is a mosquito-borne flavivirus linked to severe neuroinvasive disease. Although host and vector microRNAs (miRNAs) have been implicated in viral infection, the presence and functional relevance of WNV-encoded miRNAs remain largely unexplored. Here, we developed an integrative bioinformatics pipeline that combines multiple miRNA prediction algorithms with secondary structure screening and host transcriptomic data to identify high-confidence candidate WNV-derived mature miRNAs. Overlap-based confidence scoring and differential expression support from RNA-seq datasets prioritized a small subset of putative miRNA-mRNA interactions with potential roles in infection-associated gene regulation. A competitive endogenous RNA network constructed from predicted mRNA, lncRNA, and circRNA targets highlighted pathways involving innate immunity, GPCR and Wnt signaling, RNA degradation, and viral replication. Together, these findings provide a reproducible computational workflow and nominate testable regulatory interactions for future experimental validation.Article Citation - WoS: 1Citation - Scopus: 1Numerical Analysis and Experimental Comparison of Stress and Stiffness Parameters of Steel Reinforced Geopolymer Concrete Columns(Elsevier Sci Ltd, 2026-01) Ozbayrak, Ahmet; Kucukgoncu, Hurmet; Aslanbay, Huseyin Hilmi; Aslanbay, Yuksel Gul; Altun, FatihDespite extensive research, Geopolymer concrete (GPC) lacks reinforced concrete construction and design specifications. Developing such specifications requires comprehensive studies to promote the use of GPC, which is known for its superior performance and environmental benefits compared to ordinary Portland cement concrete (OPC). This study numerically investigated and compared the behavior and strength of fly ash-based geopolymer-reinforced concrete columns with the experimental results. Comparisons with OPC were made based on existing specifications. Herein, FEM analyses were conducted on 16 GPC and 4 OPC columns under eccentric axial compressive loads. Parameters such as eccentricity, reinforcement ratio, curing method, and activation solution ratios were varied. According to average numerical results, the GPC columns have 7% more moment capacity and 30% more curvature values than OPC. Moreover, GPC columns absorbed more energy than OPC columns. Also, GPC columns have higher axial load and bending moment carrying capacities than OPC for numerical results. Error analysis between FEM and experimental data revealed a strong correlation, with MAPE values of 8.88% (axial load) and 7.20% (moment) for GPC columns, confirming the reliability of the numerical model. ACI 318 and Eurocode 2 specifications were deemed applicable for GPC columns, provided axial loads are limited per TEC 2018.Article Citation - WoS: 39Citation - Scopus: 51What Are the Key Success Factors for Strategy Formulation and Implementation? Perspectives of Managers in the Hotel Industry(Elsevier Sci Ltd, 2020-08) Koseoglu, Mehmet Ali; Altin, Mehmet; Chan, Eric; Aladag, Omer FarukThis study investigates how hotel managers describe strategy and identify key success factors for its formulation and implementation. The study analyzes qualitative data collected through semi-structured interviews with property level top managers of hotels in Hong Kong. The findings show that hotel managers prioritize competition analysis and macro-environmental conditions over internal characteristics such as teamwork in strategy formulation. In the implementation phase, however, internal considerations such as employee involvement and strategic consensus are given prominence. This study provides a significant contribution by examining how top level practitioners in the industry interpret success factors in their strategic management efforts, and it highlights a largely neglected area in the hospitality and tourism management literature.Article Citation - WoS: 250Citation - Scopus: 280The Role of Institutional Quality and Environment-Related Technologies in Environmental Degradation for BRICS(Elsevier Sci Ltd, 2021-07) Hussain, Muzzammil; Dogan, EyupAn expanding body of literature has highlighted the environment-growth nexus. However, the literature is scarce on the role of environmental technologies and institutional quality in environmental pollution. The present study aims to contribute to the existing knowledge by utilizing environment-related technologies (ERT), institutional quality (IQ), and energy consumption to investigate ecological footprints (EF) as a proxy for the environment in BRICS economies in a framework based on environmental Kuznets curve (EKC) theory. By using data from 1992 to 2016, long-and short-term relationships are estimated through cross-section augmented autoregressive distributive lag model, augmented mean group estimator, and common correlated effects mean group. The second-generation econometric tools indicate that IQ and ERT negatively affect ecological footprints, thereby implying reductions in environmental degradation. The EKC hypothesis is not validated, implying that an increase in economic activities causes an increase in pollution. Overall, BRICS economies should improve their quality of institutions and enhance investments in environmental technologies to achieve a sustainable environment in the future. Findings are robust to practical policy implications. (c) 2021 Elsevier Ltd. All rights reserved.Article Citation - WoS: 12Citation - Scopus: 12The Role of Energy Efficiency, Renewable Resources, Green Innovation, and Fiscal Decentralization in Sustainable Development: Evidence From OECD Countries(Elsevier Sci Ltd, 2025-08) Binsaeed, Rima H.; Khan, Zeeshan; Dogan, Eyup; Rahim, SyedEnergy efficiency and renewable resources for sustainable development are novel discussion areas for academics and researchers. Similarly, most developed and emerging countries are experiencing fiscal decentralization to enhance regional development. However, the importance of these sectors in sustainable development is still unclear in the literature. This research investigates the influence of energy efficiency, renewable energy, green innovation, and fiscal decentralization on sustainable development. Using the data for 18 fiscally decentralized OECD countries from 1995 to 2020, the roles of linear and nonlinear green innovation and renewable energy are also considered. This study uses novel moment quantile regression and finds that revenue decentralization, expenditure decentralization, and fiscal decentralization are significant drivers of sustainable development. Additionally, energy efficiency and value-added manufacturing significantly enhance sustainability in the region. However, green innovation and renewables are resources that exhibit a U-shaped association with sustainable development. The robustness of these results is validated via a series of parametric and nonparametric approaches. From the policy perspective, this research suggests improved research and development on renewable energy, green innovation, and energy efficiency could significantly encourage the OECD's journey towards sustainable development. Additionally, subnational governments should be given more fiscal autonomy, which may encourage regional level investments and boost the confidence of clean energy producing sectors to accelerate sustainable regional development.Article Citation - WoS: 22Citation - Scopus: 31The Path of Least Resistance Explaining Tourist Mobility Patterns in Destination Areas Using AirBNB Data(Elsevier Sci Ltd, 2021-06) Turk, Umut; Osth, John; Kourtit, Karima; Nijkamp, PeterDestination attractiveness research has become an important research domain in leisure and tourism economics. But the mobility behaviour of visitors in relation to local public transport access in tourist places is not yet well understood. The present paper seeks to fill this research gap by studying the attractiveness profile of 25 major tourist destination places in the world by means of a 'big data' analysis of the drivers of visitors' mobility behaviour and the use of public transport in these tourist places. We introduce the principle of 'the path of least resistance' to explain and model the spatial behaviour of visitors in these 25 global destination cities. We combine a spatial hedonic price model with geoscience techniques to better understand the place-based drivers of mobility patterns of tourists. In our empirical analysis, we use an extensive and rich database combining millions of Airbnb listings originating from the Airbnb platform, and complemented with TripAdvisor platform data and OpenStreetMap data. We first estimate the effect of the quality of the Airbnb listings, the surrounding tourist amenities, and the distance to specific urban amenities on the listed Airbnb prices. In a second step of the multilevel modelling procedure, we estimate the differential impact of accessibility to public transport on the quoted Airbnb prices of the tourist accommodations. The findings confirm the validity of our conceptual framework on 'the path of least resistance' for the spatial behaviour of tourists in destination places.Article Citation - WoS: 63Citation - Scopus: 71The Nexus Between Poverty, Inequality and Environmental Pollution: Evidence Across Different Income Groups of Countries(Elsevier Sci Ltd, 2022-03) Ehigiamusoe, Kizito Uyi; Majeed, Muhammad Tariq; Dogan, EyupEven though the literature has extensively focused on a number of determinants of environmental pollution, it lacks to incorporate the importance of poverty and inequality on the environment. The nexus of poverty-inequality-environment is indeed in line with the agenda of the United Nations' Sustainable Development Goals. Furthermore, the existing studies usually rely on carbon dioxide (CO2) emissions as the proxy for the pollution in their analysis. This study fills the mentioned gaps by investigating the impacts of income inequality and poverty on environmental pollution using ecological footprint (a comprehensive measure of the pollution) in addition to CO2 emissions for 70 countries categorized by income groups. This research employs the dynamic panel system Generalized Method of Moments (GMM) and the Dumitrescu-Hurlin Granger causality techniques which are strong to several econometric issues that may frequently arise in the estimation procedures. The empirical outcomes show that income inequality and poverty increase carbon emissions and ecological footprint in the entire panel. However, when the panel is split into groups, the results indicate that income inequality mitigates carbon emissions and ecological footprint in high-income group but aggravates them in middle-income group. Though poverty has no significant impact on carbon emissions in high-income group, it raises the levels of carbon emissions and ecological footprint in middle-income group. This study overall implies that income inequality and poverty are significant determinants of environmental pollution. Hence, efforts to abate envi-ronmental degradation should give adequate attention to poverty and inequality in order to attain environmental sustainability.Article Citation - WoS: 65Citation - Scopus: 71The Nexus Between Global Carbon and Renewable Energy Sources: A Step Towards Sustainability(Elsevier Sci Ltd, 2023-09) Dogan, Eyup; Luni, Tania; Majeed, Muhammad Tariq; Tzeremes, PanayiotisThe energy transition is at the core of sustainable development as it helps to combat global warming and climate change. Similarly, carbon markets also support the climate change mitigation. Therefore, by realizing the potential role of clean energy and carbon markets in ensuring environmental sustainability, this study analyzes the spillovers and connectedness between the environment (global carbon) and renewable energy sources (wind, solar, geothermal, biofuel, and fuel cell). The empirical analysis is conducted by applying the novel "TVP-VAR" connectedness framework of Balcilar et al. (2021) on the daily data over the period from August 1, 2014, to February 4, 2022. The findings show that solar and biofuel appear as the highest net shock transmitter among alternative renewable sources while global carbon is shown as the net receiver of shocks. The largest transmission of shocks to global carbon is observed from wind followed by solar. Although these findings support the connectedness between renewable energy and the environment, however this connectedness is influenced by economic crises such as the oil crisis and pandemic crisis. During COVID-19, the fuel cell was the highest transmitter of shocks. The results are important for policy formulation, investment, and portfolio management as they provide insights into the interconnectedness and help in boosting climate actions.Article Citation - WoS: 1Citation - Scopus: 1The Impact of the COVID-19 Pandemic on Satisfaction With Healthcare Services in Türkiye(Elsevier Sci Ltd, 2024-08) Ugur, Zeynep B.; Durak, AysenurObjectives: This study aims at evaluating whether the healthcare system in Turkey performed well or not from the perspective of patients during the COVID-19 pandemic. Methods: For this purpose, we compare the satisfaction with healthcare services pre-pandemic and during the pandemic. We utilize the Life Satisfaction Survey conducted by Turkish Statistical Institute (TurkStat) between 2013 and 2021 and employ probit regression method. Results: The research results do not show any change in satisfaction with healthcare services in the pandemic years of 2020 and 2021. In addition, the satisfaction with healthcare services of people with health conditions, those without health insurance, and those whose premiums are covered by the state (green card holders) did not decrease during the pandemic period. The analysis results reveal that the satisfaction of people over 65 years old and those having health conditions with healthcare services increased during the pandemic period. Conclusion: When the findings are evaluated as a whole, we can conclude that Turkey performed well from the users' perspective during the pandemic. Public interest summary: This study analyzes the impact of the pandemic on satisfaction with healthcare services in Turkey. To do this, we utilize Life Satisfaction Survey between 2013 and 2021. The regression results indicate that satisfaction with healthcare services has not changed during the pandemic. Moreover, we report an increase in satisfaction scores for elderly and those with health conditions in the pandemic years. We also find satisfaction of people without health insurance, and those whose premiums are covered by the state (green card holders) does not change. Our analysis points Turkey did well in managing pandemic period in terms of healthcare services satisfaction.Article Citation - WoS: 12Citation - Scopus: 14The Effect of Different Tabbing Methods on the Damage Progression and Failure of Carbon Fiber Reinforced Composite Material Under Tensile Loading(Elsevier Sci Ltd, 2022-07) Ali, Hafiz Qasim; Yilmaz, Cagatay; Yildiz, MehmetComposites are well-known and widely used materials due to their anisotropic nature and high strength-to-weight ratio; therefore, the mechanical performance of these materials is crucial. Precise tensile testing is essential to obtain material properties that are crucial for the design stage of composite structures. This study is an effort to investigate the effect of adhesive materials used for tabbing process, which is necessary for the tensile testing procedure. Araldite and AF 163-2k film are used as the adhesive film, whereas in the case of AF 163-2k, tabbing is done through two different procedures (Jig and corner holes method). Apart from the tensile per-formance, strain distribution and damage progression are monitored simultaneously using digital image corre-lation (DIC) and acoustic emission (AE) analysis. It is observed that there is no significant difference in the ultimate tensile strength of these composites tabbed with different adhesives and procedures. Nevertheless, the first major failure strength is much higher in Araldite tabbed specimens compared to AF 163-2k film (the first major failure activity is defined as a point at which material loses its integrity, especially when considering structural or aerospace applications). Also, strain distribution throughout the gauge length recorded via DIC is appreciably different, which is attributed to damage accumulation and progression monitored by AE analysis. The frequency-based analysis of AE data is performed to classify the damage, and cumulative energy is correlated with the DIC to navigate the failure activity at different times and stress levels.