WoS İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/20.500.12573/394
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Conference Object Magnetic-Particle Based Signal Amplification Method Integrated With Mobile-Devices for Low Cost Biosensing(Elsevier Science Bv, 2017) Mzava, Omary; Tas, Zehra; Lafci, Vahit Can; Cakar, Mehmet Akif; Ozdur, Ibrahim; Icoz, KutayWe present a signal amplification method for biosensing applications using magnetic particles. In this method, mobile devices and simple spherical glass beads are used as a low-cost microscope to detect magnetic particles. Magnetic particles have two main functions; 1) conventionally capture, separate and transport target molecules 2) form magnetic dipoles under an applied external magnetic field to attract other magnetized particles. When magnetic particles accumulate and form a cluster, the corresponding pixel area in the image taken by the simple microscope is increased resulting in signal amplification. Current focus of new generation biosensor research is to increase the sensitivity levels of the devices to compete with current lab analysis tools while inherently having other advantages such as being low-cost, portable and simple. Biosensors based on micro/nano magnetic particles use various measurement techniques and amplification methods. In order to fully benefit from the advantages of micro/nano technology based systems, measurement set up must be also portable and have high sensitivity. Mobile devices and applications are taking place in medical fields and have high potential for future. In this work mobile devices are employed as measurement setups for the magnetic particle based sensing and signal amplification. The amplification method is not based on bimolecular binding thus cost efficient. After the images of the magnetic particles are taken, these images are sent to cloud computing for analysis by the mobile device. Matlab codes run on cloud servers for processing the images. Finally results are received and displayed on the mobile device. The mobile device based imaging system is able to detect 7 mu m size particles within a 1500 mu m x1500 mu m area and magnetic bead accumulation resulted in at least 5-fold signal amplification. The applied magnetic field is approximately 15 mT and the cost of the system excluding mobile device is under 20 cents. The method is promising for immunomagnetic bead assisted biosensors. (c) 2016 The Authors. Published by Elsevier Ltd.Conference Object MRD Biyoçip İçin Görüntü İşleme Temelli Sinyal Elde Etme Metodu(IEEE, 2019-04) Uslu, Fatma; Icoz, Kutay; Tasdemir, KasimThe response of the cancer patients to chemotherapy treatment varies from person to person. For some patients cancer cells are resistant to treatment and these cells can relapse again which is known as minimal residual disease. A microfluidic-based biochip capable of monitoring minimal residual disease is under development by our research group. The role of the biochip is to capture the target cells, which were separated by immunomagnetic beads on micro square tiles. Then biochips are imaged using a bright field optical microscope and it is planned to perform image-processing methods to detect the target cells, immunomagnetic beads and micro tiles. In this work the current progress of image processing methods for differentiating the immunomagnetic beads and micro tiles is presented.Article Ball Lens Based Mobile Microscope(Gazi Univ, 2016) Icoz, KutayIn this paper we report a low cost, simple and mobile microscope based on attachment of a ball lens to a cell phone. The system's noise and parameters affecting the image quality is investigated. The ball lens provides approximately 100X magnification and together with the cell phone's integrated lens and image sensor, 3,4-micron resolution is reached. The field-of-view of the system is 1500x1500 mu m where the price of the ball lens and the holder is less than 10 cents. By using this system as an optical light microscope, we are able to acquire images of micro particles and micro sensors. When combined with image processing methods, this optical system is capable of doing complex analysis as an alternative to commercial optical light microscopes.