WoS İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/20.500.12573/394
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Article Borax-Doped Fe2O3 and CeO2 Nanoparticles Regulate Dose-Dependently Inflammation, the Cell Cycle, and Migration in LPS-Activated THP-1 Cells(Wiley-VCH Verlag GmbH, 2026-03) Sulak, Mine; Ceylan Ekiz, Yağmur; Şen, Alaattin; Acar, Büşra; Çelik Turgut, Gurbet; Aktaş Pepe, NihanThis study examined the biological effects of borax-doped Fe2O3 and CeO2 nanoparticles (NPs) on lipopolysaccharide (LPS)-activated THP-1 cells. The morphology and composition of the nanocomposites were confirmed via scanning electron microscopy (SEM) and energy-dispersive x-ray spectroscopy (EDX). Cell viability (resazurin and crystal violet assays), apoptosis/necrosis (annexin V/propidium iodide [PI]), cell cycle (flow cytometry), migration (scratch assay), and inflammatory response (Iba1 immunofluorescence staining, inducible nitric oxide synthase [iNOS] activity, and RT-PCR) were evaluated. The particle sizes ranged from 21.34 to 33.47 nm (Fe2O3-B-NPs) and 31.07 to 36.62 nm (CeO2-B-NPs). The IC10 and IC50 dose ranges were defined for each nanocomposite and applied across different cell lines to evaluate dose-dependent biological effects. Fe2O3-B-NPs altered cell cycle progression, increasing the number of S phase cells. Both nanocomposites promoted migration at low doses but inhibited it at high doses. CeO2-B-NPs reduced Iba1 levels, whereas Fe2O3-B-NPs increased inflammatory marker levels at higher concentrations. CeO2-B-NPs suppressed TNF-alpha and IL-1 beta gene expression at the IC50 dose, while both nanocomposites reduced iNOS activity. These results indicate that the dose-dependent effects of nanocomposites should be carefully evaluated.Article Citation - WoS: 18Citation - Scopus: 17Does Islamic Inclusion of Syrians Represent a Real Challenge to Europe's Security Approach?: Dilemmas of the AKP's Syrian Refugee Discourse(Routledge Journals, Taylor & Francis Ltd, 2020) Balkilic, Ozgur; Teke Lloyd, Fatma Armagan; Balkilic, Ozgur; Teke Lloyd, Fatma ArmaganDrawing upon the critical geopolitics literature and discourse analysis, this article will explain how the ruling AKP in Turkey fashioned an alternative, Islamically infused migration discourse in response to the Syrian refugee crisis and how it depicted this as counter-hegemonic to the dominant depictions of East and West embedded within Europe's existing securitization discourse. According to the AKP's geopolitical discourse, the differing attitudes evinced in Europe and Turkey toward the Syrian migrants can be explained by civilizational values deriving from the history and religious composition of the respective regions, as between the Orient and the Occident. However, this article examines to what extent this self-promoted discourse of Islamic inclusion has succeeded in engendering a more progressive settlement and integration regime. It argues that it has actually fostered its own system of 'Othering' and has led to the development of selective admission and exclusionary practices similar to those in Europe.