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Bilgisayar Mühendisliği Bölümü Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.12573/203

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COAR Access Rights: search.filters.coarAccessRights.metadata only accessEnd date: 2019

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  • Conference Object
    In-silico Identification of Papillary Thyroid Carcinoma Molecular Mechanisms
    (IEEE, 345 E 47TH ST, NEW YORK, NY 10017 USA, 2019-04) Ersoz, Nur Sebnem; Guzel, Yasin; Bakir-Gungor, Burcu
    Representing approximately 70% to 80% of thyroid cancers, papillary thyroid cancer (PTC) is the most common type of thyroid cancers. PTC is seen in all age groups, but it is seen more frequently in women than in men. Detection of biomarker proteins of papillary thyroid cancinoma plays an important role in the diagnosis of the disease. In this study, we aim to find target genes and pathways that are associated with papillar thyroid carcinoma, by integrating different bioinformatics methods. For this purpose, usingin-silico methodologies, candidate genes and pathways that could explain disease development mechanisms are identified. Throughout this study, firstly we identified differentially expressed genes as the amount of their protein product differ between patient and healthy groups. Secondly, by using active subnetworks search algorithms, topologic analyses and functional enrichment tests, candidate proteins,which could be thought as PTC biomarkers, and affected pathways are identified.
  • Conference Object
    Citation - WoS: 1
    Citation - Scopus: 1
    A New Method to Identify Affected Pathway Subnetworks and Clusters in Colon Cancer
    (IEEE, 345 E 47TH ST, NEW YORK, NY 10017 USA, 2019-09) Goy, Gokhan; Yazici, Miray Unlu; Bakir-Gungor, Buren
    Nowadays new technological developments that play an important role in the production of big data have brought about the interpretation, sharing and storage of data related to complex diseases. Combining multi-omic data in different molecular levels is potentially important for understanding the biological origin of complex diseases. One of these complex diseases is cancer of different types, which has one of the highest causes of death worldwide. The integration of multiple omic data in the framework of a comprehensive analysis and identification of relevant pathways contribute to the development of therapeutic approaches related to disease. In this study, RNA and methylation data (genes and p values) of colon adenocarcinoma were obtained from TCGA data portal and combined with Fisher's method. While protein subnetworks affected by the disease were identified by using subnetwork algorithm, pathways related to the disease and genes associated with these pathways were determined by functional enrichment analysis. Using gene-pathway relationship matrix, kappa scores of pathways were determined by similarity calculation. In this way, the pathways were clustered according to the hierarchically optimal number, as a result, the most important pathway clusters and related genes that are effective in disease formation identified.
  • Conference Object
    Evaluation of Hybrid Classification Approaches: Case Studies on Credit Datasets
    (Springer Verlag service@springer.de, 2018) Cetiner, Erkan; Güngör, Vehbi Çağrı; Kocak, Taskin
    Hybrid classification approaches on credit domain are widely used to obtain valuable information about customer behaviours. Single classification algorithms such as neural networks, support vector machines and regression analysis have been used since years on related area. In this paper, we propose hybrid classification approaches, which try to combine several classifiers and ensemble learners to boost accuracy on classification results. We worked with two credit datasets, German dataset which is a public dataset and a Turkish Corporate Bank dataset. The goal of using such diverse datasets is to search for generalization ability of proposed model. Results show that feature selection plays a vital role on classification accuracy, hybrid approaches which shaped with ensemble learners outperform single classification techniques and hybrid approaches which consists SVM has better accuracy performance than other hybrid approaches. © 2018 Elsevier B.V., All rights reserved.
  • Article
    Operator User Management System Based on the TMF615 Standard
    (Springer, 2016) Yigit, Melike; Macit, Muhammed; Gungor, V. Cagri; Kocak, Taskin; Ozhan, Oguz
    Multi-vendor telecommunications networks in a typical service provider environment are managed using multiple proprietary user management systems (UMS), supplied by the operational support system (OSS) vendors. The management of a typical service provider includes communications solutions put into place between the global UMS and the local UMS. Nowadays, in service provider environments OSSs exist that use multi-vendor communications' protocols. In the telecommunications sector, the centralized management of all these different OSSs can cause serious problems for the network operation. In this respect, there is an urgent need for a standardized and centralized provisioning and auditing mechanism for the operators and their entitlements that work on these management systems. To address this need and to provide efficient operations among different service provider network components, this paper outlines the design and development of a TMF615 (Tele Management Forum) standard-based, common communication platform. In this respect, the proposed approach includes a common interface to address communication problems in multi-vendor, service provider environments. The interface and performance evaluations developed are some of the first solutions in this field, and the resulting solutions are converted into a commercial product with a high added value. In this regard, our proposed approach makes an important contribution to scientific literature and commercial applications. The realization of the proposed TMF615 standard-based interface enables the efficient and easy integration of existing and new OSSs of the service providers. In this way, a standardized interface is offered, along with a common communications platform adequate for all different systems. The vendors are thereby only responsible for application development based on specifications, and a standardized communications process is introduced for all related systems. This significantly facilitates the management of service providers, system performance is improved, and a massive cost reduction is provided at the same time. Consequently, the efficient management of network components is provided using a common standardized interface. In this respect, we aim to explain the TMF615 specifications; the evolution of UMS, OSSs and TMF615 with centralized UMS, as well as the implementation and performance evaluation of the TMF615 protocol are all explained in this paper.