PubMed İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/20.500.12573/397
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Article Tooth Decay Promotes Senescence in Dental Pulp Stem Cells, Modifying Their Biological and Proteomic Profiles(Wiley, 2026) Durukan, Sebahat Melike; Tez, Banu Cicek; Ozcan, Servet; Simsek, Ahmet; Al-Sammarrie, Sura Hilal Ahmed; Gunaydin, Zeynep; Acar, Mustafa BurakDental caries is a prevalent oral health problem that significantly reduces an individual's quality of life; although, it can be effectively managed through restorative treatments. Even in cases where the caries does not reach the pulp, released microbial products from the lesion can still penetrate the pulp chamber, potentially inducing stress on pulp cells. In this study, we conducted a comparative analysis of the biological and proteomic profiles of dental pulp stem cells (DPSCs) isolated from clinically asymptomatic teeth with dentinal caries that had not reached the pulp and isolated from healthy teeth. Following biological evaluations, we examined proteomes of these DPSCs by conducting a shotgun proteomics approach. Our findings show that DPSCs from decayed teeth exhibit a significantly higher proportion of senescent cells. Proteomic profiling revealed upregulation of inflammatory signaling, extracellular matrix remodeling, and senescence-associated secretory phenotype (SASP) related proteins. Additionally, we observed an upregulation in the expression of proteins associated with extracellular matrix (ECM) remodeling and components of the SASP, which are hallmarks of the senescence process. The study reveals that DPSCs can be affected by stress from carious lesions, even when the pulp appears clinically intact. Senescence and inflammatory response in these affected cells may have deleterious effects on other tissues within the organism. Consequently, restorative treatments should consider targeting not only the decayed tissue but also the senescent cells within the pulp that may have been affected by the stress induced by caries.Article The Effect of Video Modeling on Gymnastics-Based Motor Skills in Children with Autism Spectrum Disorder(MDPI, 2026) Bozdag, Berkan; Sonmez, Huseyin Gazi; Turan, Ebru; Aldhahi, Monira I.; Kilinc, Omer; Ergin, Murat; Kocak, Calik VeliBackground and Objectives: While the effectiveness of video modeling (VM) in teaching academic, daily living, and social skills to individuals with Autism Spectrum Disorder (ASD) is frequently investigated, studies examining the use of VM in teaching gymnastics-based motor skills are limited. This study aimed to examine the effects of VM on the acquisition and maintenance of a gymnastics-based motor skills in preschool children with ASD. Methods: The study employed a multiple-probe method across participants in a single-subject research design. Three preschool children diagnosed with mild ASD participated in this study. Baseline, intervention, and follow-up data were systematically collected and analyzed. Social validity data were obtained through semi-structured interviews with parents and special education teachers. Results: The percentage of correct responses increased throughout the VM intervention sessions, and all participants reached the proficiency criterion. Follow-up data collected after the intervention showed that the acquired skill was maintained, and the percentages of correct responses ranged from 80% to 100%. Social validity findings revealed that both teachers and parents perceived VM as an effective and feasible teaching approach for teaching motor skills to children with ASD. Conclusions: The research findings demonstrate that VM is an effective and socially valid teaching method for teaching and maintaining gymnastics-based motor skills in preschool children with ASD. These results contribute to the existing literature by demonstrating the applicability of video modeling in the context of gymnastics-based training.Article Performance Evaluation of Multi-Modal Radar Signal Processing in Dense Co-Existent Environments(MDPI, 2026) Norouzian, Fatemeh; Bekar, Muge; Bekar, Ali; Gashinova, Marina; Pirkani, AnumThe wide-scale deployment of radars, distributed across a platform and across multiple platforms for reliable 360 degrees situational awareness (SA), introduces the challenge of radar interference. Interference can broadly be categorised as self-interference (between radars mounted on the same platform) and mutual interference (signals received from radars on other platforms). Both types of interference impede the reliability of SA delivered by such systems, particularly in dense environments where numerous radars operate simultaneously within the same frequency band. This work presents a comprehensive evaluation of a multi-modal beamforming approach that combines unfocused synthetic aperture radar with the traditional Multiple-Input, Multiple-Output beamformer to enhance radar resolution and suppress interference. Additionally, various aspects of sensor configurations defining hardware and software capabilities of state-of-the-art radars are discussed, and a systematic analysis of signal-to-interference-plus-noise ratio at each step of the processing is presented. Extensive simulations and experimental results in both automotive and maritime environments are shown to validate the effectiveness of the proposed approach.Article Immune-Driven Mechanisms in Idiopathic Intracranial Hypertension: A Critical Synthesis(Walter de Gruyter GmbH, 2026) Tuzun, Erdem; Yetimler, BerrakIdiopathic intracranial hypertension (IIH) is increasingly recognised as a complex disorder characterized by elevated intracranial pressure (ICP), with evidence suggesting contributions from dysregulated cerebrospinal fluid (CSF) dynamics as well as metabolic, endocrine, and neurovascular mechanisms. IIH predominantly affects women of reproductive age who are living with obesity. Clinically, IIH may be asymptomatic or present with severe headaches, visual disturbances, and papilledema, with a risk of visual impairment in some untreated or refractory cases. Although the etiopathogenesis of IIH remains unclear, emerging evidence from metabolic and immunological studies suggests that immune-mediated mechanisms may contribute to disease pathophysiology. In this review, we synthesize current literature on the potential contribution of the immune system to IIH, integrating findings across obesity-associated inflammation, circulating cytokine profiles, comorbid inflammatory and autoimmune conditions, and markers of neuroglial stress and injury. We summarize converging data suggesting that IIH may, at least in part, be influenced by a pro-inflammatory milieu that affects CSF dynamics. While available studies highlight intriguing immunological signals, the underlying mechanistic pathways remain poorly resolved. Larger, longitudinal, and mechanistically grounded investigations are needed to clarify causality, identify relevant immune subtypes, and determine whether immune modulation may offer therapeutic opportunities in IIH.Article Parametric Study on the Behavior of CFRP-Strengthened Reinforced Concrete Deep Beams with Cut Circular Web Openings in Shear Spans(Nature Portfolio, 2026-02-17) Yagmur, ErenWeb openings in reinforced concrete deep beams are often necessary for functional purposes but substantially reduce structural performance. Carbon fiber-reinforced polymer (CFRP) strengthening is commonly employed to mitigate these effects. Previous studies typically examined openings in regions without stirrups or assumed closed stirrup configurations, overlooking the frequent stirrup damage that occurs in practice due to the high shear reinforcement in deep beams. In this study, three specimens from a prior experimental program were modeled in ABAQUS, and the numerical results were validated against experimental data. Openings of varying diameters were introduced by cutting reinforcements, and the beams were subsequently strengthened with CFRP laminates, and a parametric study was conducted. Results showed that increasing opening diameter markedly reduces load-carrying capacity and energy absoption, while thicker CFRP laminates partially restore performance. For example, a 300 mm opening in a 500 mm high unstrengthened beam reduced load capacity by 56% and energy absorption by 87%. Even when the opening diameter was less than one-third of the beam height, 1.8 mm CFRP laminates provided only limited improvement. Deep beam performance was strongly influenced by web opening size, and the effectiveness of CFRP strengthening was limited when stirrup integrity was compromised.Article Citation - Scopus: 4Integrated Querying and Version Control of Context-Specific Biological Networks(Oxford University Press, 2020-01-01) Coşkun, Mustafa; Grama, Ananth; Koyutürk, Mehmet; Cowman, TylerArticle Raster Orientation Effects on the Adhesion of iCVD-Deposited PSA Thin Films on FDM-Printed PLA(MDPI, 2026-01-30) Yilmaz, Kurtulus; Gursoy, Mehmet; Gunes, Aydin; Karaman, MustafaThe adhesion performance of pressure-sensitive adhesive (PSA) thin films on additively manufactured polymers is strongly governed by surface anisotropy induced during printing. In this study, PSA thin films based on 2-ethylhexyl acrylate (EHA) and acrylic acid (AA) were deposited by initiated chemical vapor deposition (iCVD) onto fused deposition modeling (FDM) printed PLA substrates with different raster orientations (0 degrees, 30 degrees, 60 degrees, and 90 degrees). The deposited films exhibited high optical transparency on glass, and thicknesses consistent with the targeted deposition. Adhesion performance was evaluated using tensile and three-point bending tests, revealing a strong dependence on raster orientation. The 0 degrees raster orientation yielded the highest shear adhesion strengths, reaching 12.03 N/cm2 under tensile loading and 4.59 N/cm2 under bending, along with the largest failure displacements. In contrast, specimens printed at 90 degrees exhibited an approximately 47% reduction in tensile shear adhesion strength and limited deformation prior to failure. SEM analysis showed that raster alignment parallel to the loading direction promoted extensive adhesive deformation and PSA fibrillation, whereas higher raster angles resulted in predominantly interfacial debonding. These results demonstrate that raster orientation is a critical design parameter for tuning PSA adhesion on FDM-printed PLA substrates without modifying adhesive chemistry.Article Follow-up of Health-Related Physical Fitness Elements in Mild Intellectual Disability for Three Years: A Sex Comparison(PeerJ Inc., 2026-03-04) Bozdağ, Berkan; Sönmez, Hüseyin Gazi; Prieto-González, Pablo; Karahan, Mustafa; Canli, Umut; Ergin, Murat; Koçak, Çalık VeliChildren with mild intellectual disability (MID) have significant limitations in both intellectual functioning and cognitive, social, and motor skill behaviors. Understanding the development of physical fitness in boys and girls with MID, and identifying sex-related differences can help devise interventional programs to improve physical fitness in these groups. The aim of this study was to compare sex differences in the time-dependent changes in health-related physical fitness components in individuals with MID. A longitudinal design was employed over three years. A total of 111 individuals with MID (46 girls and 65 boys) aged between 10 and 14 years (mean age 11.97 +/- 1.39 years) participated in the study. The physical fitness levels of the participants were assessed using the Brockport Physical Fitness Test (BPFT) battery. The tests included body composition (body height, body mass, and body mass index), aerobic endurance (15 m Progressive Aerobic Cardiovascular Endurance Run (PACER) test), and musculoskeletal function (dominant handgrip strength, back-saver sit-and-reach, and trunk lift). The results revealed that, over time, the longitudinal developmental trajectories for body mass, body height, aerobic endurance, and dominant handgrip strength were more favorable for boys. However, the longitudinal development curves for body mass index (BMI), trunk lift, and flexibility were similar for both boys and girls. The findings of this study provide valuable evidence for developing targeted physical activity programs for individuals with MID, and demonstrate the need for programs aimed at increasing aerobic endurance and muscle strength in girls with MID.Article Disorder-Engineered Hybrid Plasmonic Cavities for Emission Control of Defects in HBN(American Chemical Society, 2026-02-07) Genc, Sinan; Yucel, Oguzhan; Aglarci, Furkan; Rodriguez-Fernandez, Carlos; Yilmaz, Alpay; Caglayan, Humeyra; Bek, AlpanDefect-based quantum emitters in hexagonal boron nitride (hBN) are promising building blocks for scalable quantum photonics due to their stable single-photon emission at room temperature. However, enhancing their emission intensity and controlling the decay dynamics remain significant challenges. This study demonstrates a low-cost, scalable fabrication approach to integrate plasmonic nanocavities with defect-based quantum emitters in hBN nanoflakes. Using the thermal dewetting process, we realize two distinct configurations: stochastic Ag nanoparticles (AgNPs) on hBN flakes and hybrid plasmonic nanocavities formed by AgNPs on top of hBN flakes supported on gold/silicon dioxide (Au/SiO2) substrates. While AgNPs on bare hBN yield up to a 2-fold photoluminescence (PL) enhancement with reduced emitter lifetimes, the hybrid nanocavity architecture provides a dramatic, up to 100-fold PL enhancement and improved uniformity across multiple emitters, all without requiring deterministic positioning. Finite-difference time-domain (FDTD) simulations and time-resolved PL measurements confirm size-dependent control over decay dynamics and cavity-emitter interactions. Our versatile solution overcomes key quantum photonic device development challenges, including material integration, emission intensity optimization, and spectral multiplexity.Article Performance Boost in QLEDs Using Octanethiol-Capped Core/Shell Quantum Dots(IOP Publishing Ltd, 2026-01-07) Yazici, Ahmet F.; Yuruc, Adnan M.; Kelestemur, Yusuf; Serin, Ramis Berkay; Kacar, Rifat; Ulku, Alper; Mutlugun, EvrenQuantum dots attract significant attention as one of the most promising colloidal nanocrystals with unique optical properties and potential applications for the next generation of display technology. In this paper, we evaluate the performance of CdZnSeS-based alloyed-shell quantum dots (QDs) for electroluminescence devices upon additional shell growth and ligand exchange. This includes core/shell (C/S) and core/shell/shell (C/S/S) QDs, whose latter includes an additional ZnS shell and octanethiol (OT) ligands. We present detailed characterizations of QDs using transmission electron microscopy, XRD, and various spectroscopic techniques and demonstrate their QD light emitting (QLEDs). We find the photoluminescence quantum yield of C/S/S QDs increased from 68.8% to 88.7% compared to C/S QDs whereas the emission linewidth narrows from 22.2 nm to 20.8 nm. QLEDs fabricated with C/S/S QDs exhibit a higher peak external quantum efficiency (EQE) of 4.1% and maximum luminance of 85 000 cd m-2, compared to 2.3% EQE and 67 000 cd m-2 for C/S QLEDs. In this respect, the OT-assisted shell growth significantly improves the optical property of QDs and performance of QLEDs, likely attributed to the enhanced charge balance and increased radiative recombination rate.