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Citation - Scopus: 2
Future of Clean Cooking Energy Access in Emerging Economies by 2030
(Springer International Publishing, 2025) Çakır, Mehmet Ali; Ünlü, Ramazan; Çakir, Sümeyra Çay; Xanthopoulos, Petros
This study assesses the future of clean energy and technology access for cooking in emerging economic blocs—BRICS, MINT, ASEAN, and MENA—through 2030. Cooking contributes 3% of global greenhouse gas emissions, with over half of household emissions coming from cooking. Therefore, clean cooking energy is critical for sustainability and human health. The study aims to evaluate the likelihood of achieving the UN Sustainable Development Goal of universal clean cooking energy access by 2030 and the 2050 net-zero emissions target. Machine learning techniques, such as support vector regression, gradient boosting, and linear regression, alongside an ensemble approach, provide forecasts for these regions. The findings show a varied outlook. Within ASEAN, two countries are expected to reach 100% clean energy access for cooking by 2030, while two are likely to experience a decline. The MENA region shows stronger progress, with eight countries expected to meet the 2030 target. Among BRICS countries, only India is projected to reach full accessibility, while Russia faces a decline. The MINT countries face challenges, with none expected to meet the target, and Nigeria is projected to experience a decrease in clean energy access. The study concludes that the current trajectory makes achieving the 2030 Sustainable Development Goals and the 2050 net-zero emissions target unlikely for these regions. Policymakers must reassess their strategies and learn from successful countries to improve outcomes. © 2025 Elsevier B.V., All rights reserved.
Citation - WoS: 7
Citation - Scopus: 8
Parenting and Education: Navigating Class, Religiosity and Secularity in Istanbul
(Routledge Journals, Taylor & Francis Ltd, 2023) Kolluoglu, Biray; Dincer, Evren M.
This article studies the educational choices that secular and religious professional and managerial middle-class parents in Istanbul make for their children. It explores the ways in which class intersects with religion in Turkey where, politics, culture, social, and even economic life are marked by a deep divide among the religious and the secular. Focusing on a particular segment of the middle classes, that with higher economic and social capital, the article brings to fore the ways in which religiosity and secularity structure the processes of transforming privileges into acquired rights in the form of educational qualifications and extracurricular skills. It explores the current sociological conjuncture that bereaves both groups, albeit in different ways, of their ability to fully mobilize their accumulated economic, social, and cultural capitals in reproducing their class position in their children. The article argues that exploring the parenting of education along the secular and the religious divide can unravel the foundational elements of the ongoing competition and conflict in Turkey and enables a deeper understanding of the current divide and the potential for a future reconciliation. The study relies on a qualitative study that entails interviews with thirty families and two focus groups.
Citation - WoS: 9
Citation - Scopus: 11
Positive Solutions of the P-Laplacian Dynamic Equations on Time Scales With Sign Changing Nonlinearity
(Texas State Univ, 2018) Dogan, Abdulkadir
This article concerns the existence of positive solutions for p-Laplacian boundary value problem on time scales. By applying fixed point index we obtain the existence of solutions. Emphasis is put on the fact that the nonlinear term is allowed to change sign. An example illustrates our results.
Citation - Scopus: 1
A Gendered Analysis of Palestinian Refugee Women's Experiences of Migration From Syria to Türkiye
(Sage Publications Ltd, 2024) Kurtoglu, Ayca; Llyod, Armagan Teke; Salimoglu, Zafer
After the outbreak of the conflict in 2011, millions of people fled Syria across its borders. This gave way to a new category of people, "Syrian refugees." While this categorical understanding constitutes the basis for legal entitlements, it homogenizes all fleeing Syria and results in concealing the differential experiences and vulnerabilities of particular groups. The paper challenges this blanket categorization by focusing on the migration experiences of Palestinian women from Syria to Turkiye around the concepts of biological and social reproduction which represent the largely neglected aspects concerning the process of forced migration. By drawing on six women's experiences, the paper concludes that the homogeneity of the Syrian migrants is an illusion; women's migrations are shaped through their gendered and ethnic history; and women face gender-specific challenges and opportunities in both home and host countries. We particularly argue that policies on border control and migrant's integration fail to consider the subjective conditions and needs of particular groups within the Syrian migrants.
Citation - WoS: 4
Citation - Scopus: 9
Are We Ready for the New Normal in E-Business Education? Sentiment Analysis of Learners' Opinions on MOOCs
(Russian State Vocational Pedagogical Univ, 2021) Derindag, O. F.; Cizmeci, B.
Introduction. The new digital economy and its constantly evolving paradigm have completely transformed the model of doing business and the learning methods. MOOCs (massive-open-online-courses) and micro-credentials are the educations interfaces, have become an important teaching environment tool. Distance learning has become an indispensable alternative teaching method in updating and transferring classical education materials according to real-world settings, especially for learners in higher education. Aim. The current research is aimed to address the society's readiness and attitude direction to the concept of MOOCs and distance learning, highlighting its emergence and inevitability for educational institutions of all types in order to make a fundamental change in their curricula, especially in e-business courses, which are the most demanded training courses on MOOCs platforms. Methodology and research methods. In the study, the awareness and recognition of the online community on the MOOCs concept is examined. in this direction, Turkish people's perception and attitudes toward MOOCs have been addressed via sentiment analysis on Eksi Sozluk, the largest social communication and discussion platform in Turkey. Results. According to the sentiment analysis results, it has been determined that 52% of respondents have positive judgments on distance education and MOOCs, 29% of responses are neutral and 18% are negative. In general, distance education and MOOCs are perceived as a useful new education model by the Turkish people. Scientific novelty. This paper is the first sentiment analysis of learners' opinions on MOOCs and distance learning in Turkey. Considering the increasing awareness of MOOCs and the need for e-business education, as the most demanded type of MOOCs, this is the first study investigating the priority of these two phenomena within the context of COVID-19. Practical significance. It is thought that this study will contribute to the stakeholders in terms of showing how MOOCs and micro-credentials have a high potential to understanding trends in education especially in the new normal after the COVID-19 pandemic. The holistic education model of institutions has difficulty meeting the competitive nature and result-oriented approach of the e-business ecosystem. This market reality requires the institutions to offer more to-the-point and applied education solutions. In terms of e-business (e-commerce, digital marketing) education, the importance of MOOCs as a solution-focused on "how" rather than "what." has been comprehensively discussed in the paper.
Citation - WoS: 9
Citation - Scopus: 10
An Answer to Colon Cancer Treatment by Mesenchymal Stem Cell Originated from Adipose Tissue
(Mashhad Univ Med Sciences, 2018) Iplik, Elif Sinem; Ertugrul, Baris; Kozanoglu, Ilknur; Baran, Yusuf; Cakmakoglu, Bedia
Objective(s): Colon cancer is risen up with its complex mechanism that directly impacts on its treatment as well as its common prevalence. Mesenchymal stem cells (MSCs) have been considered as a therapeutic candidate for conventional disease including cancer. In this research, we have focused on apoptotic effects of adipose tissue-derived MSCs in colon cancer. Materials and Methods: MSCs were obtained from adipose tissue and characterized by Flowcytometer using suitable antibodies. MSCs, HT-29, HCT-116, RKO and healthy cell line MRC5 were cultured by different seeding procedure. After cell viability assay, changes in caspase 3 enzyme activity and the level of phosphatidylserine were measured. Results: For cell viability assay, a 48 hr incubation period was chosen to seed all cells together. There was a 1.36-fold decrease in caspase 3 enzyme activity by co-treatment of RKO and MSCs in addition to 2.02-fold decrease in HT-29 and MSCs co-treatment, and 1.103-fold increase in HCT-116 and MSCs. The results demonstrated that HCT-116 led to the highest rate of apoptotic cell death (7.5%) compared with other cells. Conclusion: We suggest that MSCs might remain a new treatment option for cancer by its differentiation and repair capacity.
Citation - WoS: 2
Citation - Scopus: 4
Effect of Geometry Modifications on the Vectoring Performance of a Controlled Jet
(Isfahan University of Technology secretary@jafmonline.net, 2017) Tomac, Mehmet N.
Jet vectoring performances of ten different designs with various depths and geometrical outlines were quantified through constant temperature anemometry measurements for a Reynolds number range from 10,000 to 30,000 by using passive and active flow control methods at cold flow. The reference design was based on NASA's double throat nozzle concept and a self-injection double throat nozzle design that uses similar flow control concept as the reference design, were also tested for performance comparison. Furthermore, jet vectoring performance of a single throat design, utilizing Coanda effect for jet vectoring, was also quantified. Results indicated jet vectoring angles starting from 2° up to 47° for a control jet flow rate range from 1% up to 10% with respect to the primary jet flow rate in the investigated Re range. Maximum jet vectoring angle was achieved with a single throat design which incorporates small step geometry before the Coanda surface for more effective flow attachment and these results were compared with the vectoring performance of the double throat nozzle designs. © 2018 Elsevier B.V., All rights reserved.
Citation - WoS: 1
Citation - Scopus: 2
Is Artificial Intelligence a Trustworthy Route Navigation System for Smart Urban Planning
(Univ Alexandru Ioan Cuza, Centrul Studii Europene, 2024) Kourtit, Karima; Nijkamp, Peter; Osth, John; Turk, Umut
In the age of smart or intelligent cities, the use of Artificial Intelligence (AI) presents a spectrum of new opportunities and challenges for both the research and policy community. The present study explores the intricate interplay between AI-generated content and actual choice spectra in urban planning. It focuses on the concept of 'city intelligence' and related AI concepts, underscoring the pivotal role of AI in addressing and understanding the quality of life in contemporary urban environments. As AI continues its transformative impact on communication and information systems in the realm of urban planning, this study brings to the forefront key insights into the challenges of validating AI-based information. Given the inherently subjective nature of AIgenerated content, and its influential role in shaping user-perceived value, AI will most likely be a game changer catalyzing enhancements in the urban quality of life and inducing favorable urban developments. Additionally, the study also addresses the significance of the so-called 'Garbage-in Garbage-out' (GiGo) principle and 'Bullshitin Bullshit out' (BiBo) principle in validating AI-generated content, and seeks to enhance our understanding of the spatial information landscape in urban planning by introducing the notion of an urban X'XQ' performance production function.
Citation - WoS: 3
Citation - Scopus: 3
Robust Reactivity, Neutron Source, and Precursor Estimators for Nuclear Reactors
(Elsevier Science SA, 2013) Ablay, Gunyaz
Reactivity, precursor concentration, and external neutron source strength determine control, operation and performance of nuclear reactors. These main reactor quantities are not directly measurable and must be calculated or estimated using reactor kinetics. This study presents efficient and robust nonlinear estimation algorithms for predicting these fundamental reactor quantities. The effectiveness of the proposed estimators is assessed through chirp and step test signals in the presence of parameter uncertainties and measurement noise. (C) 2013 Elsevier B.V. All rights reserved.
A Decision Support System for the Prediction of Mortality in Patients With Acute Kidney Injury Admitted in Intensive Care Unit
(Univ South Bohemia, 2020) Kayaalti, Selda; Kayaalti, Omer; Aksebzeci, Bekir Hakan
Intensive care unit (ICU) is a very special unit of a hospital, where healthcare professionals provide treatment and, later, close followup to the patients. It is crucial to estimate mortality in ICU patients from many viewpoints. The purpose of this study is to classify the status of patients with acute kidney injury (AKI) in ICU as early mortality, late mortality, and survival by the application of Classification and Regression Trees (CART) algorithm to the patients' attributes such as blood urea nitrogen, creatinine, serum and urine neutrophil gelatinase-associated lipocalin (NGAL), alkaline phosphatase, lactate dehydrogenase (LDH), gamma-glutamyl transferase, laboratory electrolytes, blood gas, mean arterial pressure, central venous pressure and demographic details of patients. This study was conducted 50 patients with AKI who were followed up in the ICU. The study also aims to determine the significance of relationship between the attributes used in the prediction of mortality in CART and patients' status by employing the Kruskal-Wallis H test. The classification accuracy, sensitivity, and specificity of CART for the tested attributes for the prediction of early mortality, late mortality, and survival of patients were 90.00%, 83.33%, and 91.67%, respectively. The values of both urine NGAL and LDH on day 7 showed a considerable difference according to the patients' status after being examined by the Kruskal-Wallis H test.
Citation - WoS: 1
Citation - Scopus: 10
Existence of Three Positive Solutions for an M-Point Boundary-Value Problem on Time Scales
(Texas State Univ, 2013) Dogan, Abdulkadir
We study an m-point boundary-value problem on times scales. By using a fixed point theorem, we prove the existence of at least three positive solutions, under suitable growth conditions imposed on the nonlinear term. An example is given to illustrate our results.
An Evaluation of the Rural Landscapes as Heritage From Habitus Perspective
(Geleneksel Yayincilik Ltd Stl, 2024) Elagoz Timur, Bahar; Asiliskender, Burak
Rural heritage areas consist of natural and built environments produced concerning local and traditional life practices, production -consumption habits, and intangible values of societies. This environment is created vernacularly using local materials and construction techniques due to the topographical features where it is built and is in contact with local users. For this reason, it is valuable to explain the meaning of vernacular architecture to understand its users and the habitus that emerges from it. Historical rural settlements, which have found their place in conservation theories over time, attract attention with their traditional and vernacular architecture.These areas, called "rural landscape as heritage" by definition developed by ICOMOS-IFLA, are accepted as a whole with their tangible and intangible components such as natural, archaeological, and architectural. Today, plenty of research is about integrated conservation issues of rural landscape heritages. The study, differently from theirs, plans to discuss the rural landscapes through habitus. It is possible to interpret the vernacular architecture produced in rural landscapes by understanding its user and the habitus in which it emerges. Moreover, there is a dynamic link between the traditional rural areas and the habitus of societies that produce and are produced by their daily lifestyles, traditions, collective memories, and histories. The habitus, which is always transformed, begins to adapt its environment to the change by this link. In this changing process, effects such as industrialization, technological developments, and globalization threaten rural landscapes to lose their authentic values. The first step in the conservation of rural landscapes lies in understanding these areas and their values and making change predictable. From this point of view, this study questions the role of habitus in the formation and life cycle of rural heritage. The research and the hypothesis created aim to contribute to the studies about sustainable living in rural landscapes by revealing the structuring effect of the habitus between the rural landscapes and their natural, built, and socio-cultural environments. In the study, the method developed from the literature to understand rural landscapes and their dynamics without studying the case is presented for use in rural landscape heritage conservation studies. Habitus connects the natural, tangible, and intangible components of rural landscapes by the balance it creates and contributes to the formation and maintenance of the spirit of place. In order to understand this balance and draw attention to holistic conservation approaches, the network of relations has been tried to be revealed in detail. Within the scope of the study, the definition of habitus was explained through the environment and practices, and its relationship with the rural landscape was conveyed through a single structure and settlement. The transition of living heritage is inevitable, but when it cannot be managed according to international regulations, the consequences will be the loss of rural heritage, which represents societies' traditional lifestyles. The proposed approach needs to be customized and re-established for each different rural landscape heritage site. Because each heritage site is unique and has its own conservation problems. It is critical to raise awareness about the effects of habitus change in rural landscapes and their management and to emphasize the importance of creating resilient rural heritage areas that can accompany change by preserving authentic values.
Citation - WoS: 23
Citation - Scopus: 23
Pressure-Induced Amorphization of MOF-5: A First Principles Study
(Wiley-VCH Verlag GmbH, 2018) Erkartal, Mustafa; Durandurdu, Murat; Erkartal, Mustafa; Durandurdu, Murat
Amorphous metal-organic frameworks (MOFs) and the amorphization of crystalline MOFs under mechanical stimuli are attracting considerable interest in last few years. However, we still have limited knowledge on their atomic arrangement and the physical origin of crystalline-to-amorphous phase transitions under mechanical stimuli. In this study, ab initio simulations within a generalized gradient approximation are carried out to investigate the high-pressure behavior of MOF-5. Similar to the previous experimental findings, a pressure-induced amorphization is observed at 2 GPa through the simulations. The phase transformation is an irreversible first order transition and accompanied by around 68% volume collapse. Remarkably, the transition arises from local distortions and, contrary to previous suggestions, does not involve any bond breaking and formation. Additionally, a drastic band gap closure is perceived for the amorphous state. This study has gone some way towards enhancing our understanding of pressure-induced amorphization in MOFs.
Citation - WoS: 1
Citation - Scopus: 2
Discovery of a C-S Lyase Inhibitor for the Prevention of Human Body Malodor Formation: Tannic Acid Inhibits the Thioalcohol Production in Staphylococcus Hominis
(Springer, 2025) Fidan, Ozkan; Karipcin, Ayse Doga; Kose, Ayse Hamide; Anaz, Ayse; Demirsoy, Beyza Nur; Arslansoy, Nuriye; Mujwar, Somdutt
Human body odor is a result of the bacterial biotransformation of odorless precursor molecules secreted by the underarm sweat glands. In the human axilla, Staphylococcus hominis is the predominant bacterial species responsible for the biotransformation process of the odorless precursor molecule into the malodorous 3M3SH by two enzymes, a dipeptidase and a specific C-S lyase. The current solutions for malodor, such as deodorants and antiperspirants are known to block the apocrine glands or disrupt the skin microbiota. Additionally, these chemicals endanger both the environment and human health, and their long-term use can influence the function of sweat glands. Therefore, there is a need for the development of alternative, environmentally friendly, and natural solutions for the prevention of human body malodor. In this study, a library of secondary metabolites from various plants was screened to inhibit the C-S lyase, which metabolizes the odorless precursor sweat molecules, through molecular docking and molecular dynamics (MD) simulation. In silico studies revealed that tannic acid had the strongest affinity towards C-S lyase and was stably maintained in the binding pocket of the enzyme during 100-ns MD simulation. We found in the in vitro biotransformation assays that 1 mM tannic acid not only exhibited a significant reduction in malodor formation but also had quite low growth inhibition in S. hominis, indicating the minimum inhibitory effect of tannic acid on the skin microflora. This study paved the way for the development of a promising natural C-S lyase inhibitor to eliminate human body odor and can be used as a natural deodorizing molecule after further in vivo analysis.
Citation - WoS: 12
Citation - Scopus: 14
4D-QSAR Investigation and Pharmacophore Identification of Pyrrolo[2,1-C][1,4]Benzodiazepines Using Electron Conformational-Genetic Algorithm Method
(Taylor & Francis Ltd, 2016) Ozalp, A.; Yavuz, S. C.; Sabanci, N.; Copur, F.; Kokbudak, Z.; Saripinar, E.
In this paper, we present the results of pharmacophore identification and bioactivity prediction for pyrrolo[2,1-c][1,4]benzodiazepine derivatives using the electron conformational-genetic algorithm (EC-GA) method as 4D-QSAR analysis. Using the data obtained from quantum chemical calculations at PM3/HF level, the electron conformational matrices of congruity (ECMC) were constructed by EMRE software. The ECMC of the lowest energy conformer of the compound with the highest activity was chosen as the template and compared with the ECMCs of the lowest energy conformer of the other compounds within given tolerances to reveal the electron conformational submatrix of activity (ECSA, i.e. pharmacophore) by ECSP software. A descriptor pool was generated taking into account the obtained pharmacophore. To predict the theoretical activity and select the best subset of variables affecting bioactivities, the nonlinear least square regression method and genetic algorithm were performed. For four types of activity including the GI(50), TGI, LC50 and IC50 of the pyrrolo[2,1-c][1,4] benzodiazepine series, the r(train)(2), r(test)(2) and q(2) values were 0.858, 0.810, 0.771; 0.853, 0.848, 0.787; 0.703, 0.787, 0.600; and 0.776, 0.722, 0.687, respectively.
Citation - WoS: 2
Citation - Scopus: 2
Possible Boron-Rich Amorphous Silicon Borides From Ab Initio Simulations
(Springer, 2023) Karacaoglan, Aysegul Ozlem Cetin; Durandurdu, Murat
ContextBy means of ab initio molecular dynamics simulations, possible boron-rich amorphous silicon borides (BnSi1-n, 0.5 <= n <= 0.95) are generated and their microstructure, electrical properties and mechanical characters are scrutinized in details. As expected, the mean coordination number of each species increases progressively and more closed packed structures form with increasing B concentration. In all amorphous models, pentagonal pyramid-like configurations are observed and some of which lead to the development of B-12 and B11Si icosahedrons. It should be noted that the B11Si icosahedron does not form in any crystalline silicon borides. Due to the affinity of B atoms to form cage-like clusters, phase separations (Si:B) are perceived in the most models. All simulated amorphous configurations are a semiconducting material on the basis of GGA+U calculations. The bulk modulus of the computer-generated amorphous compounds is in the range of 90 GPa to 182 GPa. As predictable, the Vickers hardness increases with increasing B content and reaches values of 25-33 GPa at 95% B concentration. Due to their electrical and mechanical properties, these materials might offer some practical applications in semiconductor technologies.MethodThe density functional theory (DFT) based ab initio molecular dynamics (AIMD) simulations were used to generate B-rich amorphous configurations.
Citation - WoS: 2
Citation - Scopus: 3
Characterization of Nickel in Chromite Beneficiation Tailings by Mineral Liberation Analysis and Its Recovery by H2SO4 Leaching Followed by Oxalic Acid Precipitation
(Springer, 2024) Altiner, Mahmut; Ibrahim, Ahmedaljaali Ibrahim Idrees; Kursunoglu, Sait; Top, Soner; Bayat, Oktay
This study investigated the recovery of nickel from tailings (0.2% Ni) obtained in a chromite beneficiation plant using H2SO4 leaching followed by oxalic acid precipitation. The tailings were characterized using mineral liberation analysis. Ni was found as Fe-Ni, Fe-Ni-Co sulfide minerals, which were encapsulated in serpentine, olivine, pyroxene and clinochlore. Liberated fine chromite minerals benefited from magnetic separation followed by Falcon concentrator. A chromite product with a grade > 37% was obtained. The effect of leaching conditions including acid concentration, temperature, time and solid-to-liquid ratio on the leaching behavior of Ni was investigated based on the Taguchi approach. It was possible to extract Ni with a rate of > 98% from the tailings using the following conditions: H2SO4 concentration of 3 M, solid-to-liquid ratio of 1:20 and ambient temperature for 2 h. Finally, Ni was precipitated as an oxalate form with a precipitation rate of 72%. It is believed that implementing additional purification methods like solvent extraction may be essential to obtain a high-purity nickel product from the leach solution of oxalate precipitate. Experimental results indicate that the tailings used in this study are a good alternative as Ni resource in the near future.
Citation - WoS: 25
Citation - Scopus: 29
Evaluation of the Sensory Correlation Between Touch Sensitivity and the Capacity to Discriminate Viscosity
(Wiley-Blackwell, 2015) Aktar, Tugba; Chen, Jianshe; Ettelaie, Rammile; Holmes, Melvin
The capacity to discriminate the viscous nature of food materials is critically important in the sensory evaluation and subsequent perception of food texture and acceptability. It is generally assumed that this capability is closely linked to individual's tactile sensitivity, which in itself is a function of the individual's specific capabilities due to experience, age, lifestyle and health status for example. However, no experimental evidence is yet available to validate or disprove this assumption. By comparing the touch sensitivity and the capability of viscosity discrimination among individuals (using finger and tongue sensory perception), this work aims to establish if a correlation exists. Semmes-Weinstein monofilaments were used for touch sensitivity tests of the index fingers and tongue surfaces. A series of syrup solutions were prepared to give a wide range of viscosities with a viscosity scale factor of 1.20.009. A total of 30 healthy subjects (16 female and 14 male; mean age 29.9 +/- 9 years; mean body mass index 22.5 +/- 2.9kg/m(2)) participated in this study. A similar touch sensitivity threshold, 0.023 and 0.021g, was observed for the index fingertip and for the tongue, respectively. However, the tongue appears to be more sensitive to touch than the fingertips when the force range they cover was compared. The viscosity discrimination threshold was found to be approximately 53% for the index fingertip and around 47% for the tongue. By comparing individual capabilities of viscosity discrimination against touch sensitivity, no significant correlation was observed between the two factors. The results from this work suggest that the capability to discriminate viscosity differences is more likely attributed to experience and is little influenced by one's physiological capability of tactile sensation, e.g., the touch sensitivity. Practical ApplicationsThe capability to discriminate differences in viscosity and the subsequent perception is an important factor for food texture appreciation. Establishment of the underlying factors that characterize the variation in the ability for such discrimination across individuals is not only critically important for our fundamental understanding of the viscosity perception but is also hugely important for the food industry in development of new food products, and in particular for specific food design for individuals with special needs, e.g., elderly, dysphagia patients, etc. Differential threshold for certain tastes and aroma compounds has been investigated. However, little has been reported in the literature about the tactile interpretation of viscosity sensation and perception. Findings from this work could provide new insight for researchers in the food industry and in food development by giving them flexibility to redesign their ingredients especially the one that has thickening effect on the product viscosity. Methodologies used in this experiment could also be applied for general food sensory studies in establishing relationships between sensory psychology and sensory physiology and especially the threshold studies with a similar approach of finding just noticeable difference values of any stimuli. The method could also be applicable to sensory capability studies of some particular groups such as elderly people to assess how weakened physiology affects their sensory capability.
Citation - WoS: 1
Citation - Scopus: 1
Concurrent Inhibition of FLT3 and Sphingosine Kinase-1 Triggers Synergistic Cytotoxicity in Midostaurin Resistant FLT3-ITD Positive Acute Myeloid Leukemia Cells via Blocking FLT3/TAT5A Signaling to Induce Apoptosis
(Taylor & Francis Ltd, 2025) Tecik, Melisa; Adan, Aysun
The FMS-like tyrosine kinase 3-internal tandem duplication (FLT3-ITD) is one of the most frequent mutations observed in acute myeloid leukemia (AML) which contributes to disease progression and unfavorable prognosis. Midostaurin, a small FLT3 inhibitor (FLT3I), is clinically approved. However, patients generally possess acquired resistance when midostaurin used alone. Shifting the balance in the sphingolipid rheostat toward anti-apoptotic sphingosine kinase-1 (SK-1) or glucosylceramide synthase (GCS) is related to therapy resistance in cancer, however, their role in midostaurin resistant FLT3-ITD positive AML has not been previously investigated. We generated midostaurin resistant MV4-11 and MOLM-13 cell lines which showed increased IC50 values compared to their sensitive partner cells. SK-1 is overexpressed in resistant cells while GCS remains unchanged. Subsequent pharmacological targeting of SK-1 in resistant cells decreased SK-1 protein level, inhibited cell proliferation and showed additive or synergistic effect on cell growth, as confirmed by the Chou-Talalay combination index, and induced G0/G1 arrest (PI staining by flow cytometry). Cotreatment (SKI-II plus midostaurin) triggered apoptosis via phosphatidylserine exposure (annexin V/PI double staining). Mechanistically, induction of the intrinsic pathway of apoptosis was confirmed as increased activating cleavages of caspase-3 and PARP and increased Bax/Bcl-2 ratios. Activating phosphorylations of FLT3 (at tyrosine residue 591) and STAT5A (at tyrosine residue 694) dramatically inhibited in resistant cells treated with the combination. In conclusion, midostaurin resistance could be reversed by dual SK-1 and FLT3 inhibition in midostaurin resistant AML cell lines, providing the first evidence of a novel treatment approach to re-sensitize FLT3-ITD positive AML.
Citation - WoS: 26
Citation - Scopus: 31
miRcorrNet: Machine Learning-Based Integration of miRNA and mRNA Expression Profiles, Combined with Feature Grouping and Ranking
(PeerJ Inc., 2021) Yousef, M.; Göy, G.; Mitra, R.; Eischen, C.M.; Jabeer, A.; Bakir-Güngör, B.
A better understanding of disease development and progression mechanisms at the molecular level is critical both for the diagnosis of a disease and for the development of therapeutic approaches. The advancements in high throughput technologies allowed to generate mRNA and microRNA (miRNA) expression profiles; and the integrative analysis of these profiles allowed to uncover the functional effects of RNA expression in complex diseases, such as cancer. Several researches attempt to integrate miRNA and mRNA expression profiles using statistical methods such as Pearson correlation, and then combine it with enrichment analysis. In this study, we developed a novel tool called miRcorrNet, which performs machine learning-based integration to analyze miRNA and mRNA gene expression profiles. miRcorrNet groups mRNAs based on their correlation to miRNA expression levels and hence it generates groups of target genes associated with each miRNA. Then, these groups are subject to a rank function for classification. We have evaluated our tool using miRNA and mRNA expression profiling data downloaded from The Cancer Genome Atlas (TCGA), and performed comparative evaluation with existing tools. In our experiments we show that miRcorrNet performs as good as other tools in terms of accuracy (reaching more than 95% AUC value). Additionally, miRcorrNet includes ranking steps to separate two classes, namely case and control, which is not available in other tools. We have also evaluated the performance of miRcorrNet using a completely independent dataset. Moreover, we conducted a comprehensive literature search to explore the biological functions of the identified miRNAs. We have validated our significantly identified miRNA groups against known databases, which yielded about 90% accuracy. Our results suggest that miRcorrNet is able to accurately prioritize pan-cancer regulating high-confidence miRNAs. miRcorrNet tool and all other supplementary files are available at https://github.com/ malikyousef/miRcorrNet. © 2021 Elsevier B.V., All rights reserved.

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