Yaşam ve Doğa Bilimleri Fakültesi

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Computational Detection of Pre-microRNAs
(Humana Press Inc., 2022) Saçar Demirci, Müşerref Duygu; 0000-0003-2012-0598; AGÜ, Yaşam ve Doğa Bilimleri Fakültesi, Biyomühendislik Bölümü; Saçar Demirci, Müşerref Duygu
MicroRNA (miRNA) studies have been one of the most popular research areas in recent years. Although thousands of miRNAs have been detected in several species, the majority remains unidentified. Thus, finding novel miRNAs is a vital element for investigating miRNA mediated posttranscriptional gene regulation machineries. Furthermore, experimental methods have challenging inadequacies in their capability to detect rare miRNAs, and are also limited to the state of the organism under examination (e.g., tissue type, developmental stage, stress-disease conditions). These issues have initiated the creation of high-level computational methodologies endeavoring to distinguish potential miRNAs in silico. On the other hand, most of these tools suffer from high numbers of false positives and/or false negatives and as a result they do not provide enough confidence for validating all their predictions experimentally. In this chapter, computational difficulties in detection of pre-miRNAs are discussed and a machine learning based approach that has been designed to address these issues is reviewed.
Isothiocyanates as drug candidates in cancer prevention and treatment
(IGI Global, 2023) Saylan, Demet; Cebeci, Fatma; AGÜ, Yaşam ve Doğa Bilimleri Fakültesi, Moleküler Biyoloji ve Genetik Bölümü; Saylan, Demet
Cancer is the second most common cause of death worldwide. Many methods such as surgery, chemotherapy, radiation therapy, etc. are being used for treatment. Most patients have a combination treatment with chemotherapy along with surgery or radiotherapy or both. Chemotherapy kills cancer cells by preventing them from reproducing, growing, and spreading in the body. Recently, safer alternatives to chemotherapy have been discovered and developed, as most of the drugs used in cancer treatment have side effects and a serious impact on patient comfort. As an alternative, the phytochemicals found in daily consumed plants are attractive candidates for clinical/pre-clinical evaluation because of their higher safety. In this context, certain degradation products of glucosinolates (isothiocyanates) are promising agents for cancer prevention and treatment.
Pleiotropic molecular effects of dietary polyphenols resveratrol and apigenin in Leukemia
(ELSEVIER, 2018) Adan, Aysun; Oğuz, Osman; 0000-0002-3747-8580; AGÜ, Yaşam ve Doğa Bilimleri Fakültesi, Moleküler Biyoloji ve Genetik Bölümü; Adan, Aysun; Oğuz, Osman
Resveratrol and apigenin are commonly found polyphenols in many fruits and vegetables and recognition of these dietary polyphenols for human health owing to their biological and pharmacological features including antiinflammatory and antioxidative functions has increased recently. In addition to direct antioxidative effects, they have impacts on various important signaling pathways dysregulated in cancer, genetic and epigenetic regulators, transcription factors and even on miRNAs as anticarcinogenic compounds. Numerous in vitro and in vivo studies have demonstrated their pleiotropic molecular mechanisms of action in cancer, particularly in solid tumors. However, in recent years, significant progress has been made in studying the antileukemic effects of resveratrol and apigenin at the cellular and molecular levels. Herein, we have critically discussed the main molecular targets of resveratrol and apigenin and their promising potential as chemopreventive agents as well as their limitations, with a special emphasis on leukemias.

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Browsing Yaşam ve Doğa Bilimleri Fakültesi by Publication Category "Kitap Bölümü - Uluslararası"