Browsing by Author "Tasdemir, Arzu"

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    Article
    Citation - WoS: 16
    Citation - Scopus: 17
    Can Laws Be a Potential PET Image Texture Analysis Approach for Evaluation of Tumor Heterogeneity and Histopathological Characteristics in NSCLC
    (Springer, 2018) Karacavus, Seyhan; Yilmaz, Bulent; Tasdemir, Arzu; Kayaalti, Omer; Kaya, Eser; Icer, Semra; Ayyildiz, Oguzhan
    We investigated the association between the textural features obtained from F-18-FDG images, metabolic parameters (SUVmax(,) SUVmean, MTV, TLG), and tumor histopathological characteristics (stage and Ki-67 proliferation index) in non-small cell lung cancer (NSCLC). The FDG-PET images of 67 patients with NSCLC were evaluated. MATLAB technical computing language was employed in the extraction of 137 features by using first order statistics (FOS), gray-level co-occurrence matrix (GLCM), gray-level run length matrix (GLRLM), and Laws' texture filters. Textural features and metabolic parameters were statistically analyzed in terms of good discrimination power between tumor stages, and selected features/parameters were used in the automatic classification by k-nearest neighbors (k-NN) and support vector machines (SVM). We showed that one textural feature (gray-level nonuniformity, GLN) obtained using GLRLM approach and nine textural features using Laws' approach were successful in discriminating all tumor stages, unlike metabolic parameters. There were significant correlations between Ki-67 index and some of the textural features computed using Laws' method (r = 0.6, p = 0.013). In terms of automatic classification of tumor stage, the accuracy was approximately 84% with k-NN classifier (k = 3) and SVM, using selected five features. Texture analysis of FDG-PET images has a potential to be an objective tool to assess tumor histopathological characteristics. The textural features obtained using Laws' approach could be useful in the discrimination of tumor stage.
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    Conference Object
    Prognostic Significance of the Texture Features Determined Using Three Dimensional 18F-FDG PET Images: New Potential Biomarkers
    (Soc Nuclear Medicine inc, 2016) Karacavus, Seyhan; Yilmaz, Bulent; Kayaalti, Omer; Tasdemir, Arzu; Kaya, Eser; Icer, Semra; Asyali, Musa