Browsing by Author "Tarhan, Seray Zora"

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Botyrococcus Braunii Cultivation in the Wet Oxidation Liquid From the Hydrothermal Carbonization of Orange Pomace
(Mehmet Sinan Bilgili, 2020) Tarhan, Seray Zora; Kocer, Anil Tevfik; Ozcimen, Didem; Gokalp, Iskender
Food waste is a worldwide problem that leads to both food scarcities and environmental issues. A very important fraction of food waste is landfilled and constitutes sources of carbon dioxide and methane by anaerobic digestion, contributing therefore to global warming. Hydrothermal carbonization (HTC) is a specific thermochemical conversion process converting very wet organic waste streams to a valuable energy-rich hydrochar. However, the process water issuing from the HTC should also be post treated as it includes high amounts of carbon and several toxic chemicals. In the present study, we treated the aqueous phase of the HTC process by wet oxidation (WO) and we used the resulting liquid as a culture medium for micro algal growth. This method is applied in this study to the process water of HTC treatment of orange pomace which is an organic waste generated in considerable amounts around the world. Botyrococcus braunii was used as the algal strain. The results showed that B.braunii can be efficiently cultivated in the WO liquid, especially for low dilution rates. It has been therefore demonstrated that this integrated approach provides a low cost nutriment medium for algal growth and contributes to the sustainable remediation of the HTC process water.
Citation - WoS: 1
Citation - Scopus: 1
Cinnamomum Zeylanicum Extract Incorporated Electrospun Poly(Lactic Acid)/ Gelatin Membrane as a New Wound Dressing
(Elsevier, 2025) Tarhan, Seray Zora; Pepe, Nihan Aktas; Sen, Alaattin; Isoglu, Ismail Alper
In this study, we fabricated poly(lactic acid)/gelatin electrospun membranes containing various concentrations of Cinnamomum zeylanicum extract and evaluated them as a novel wound dressing. The electrospun membranes were chemically, morphologically, and mechanically characterized, and the results were discussed in comparison with the literature. Electrospun membranes' biodegradability, swelling, and release properties were evaluated, with the CE7.5 membrane having values of 29.60 f 7.20 and 542.1 f 48.3 % and 66.9 %, respectively. Antibacterial activity was observed in CE7.5 and CE10 membranes against E. coli and S. aureus strains. At the highest concentration (CE10), 111.7 f 5.6 % and 96 f 12.375 % cell viability were detected in fibroblasts and differentiated LPS-induced THP-1 cells. Cell viability was further evaluated by Annexin-V/PI staining, revealing that 97.95 f 1.63 % of the cells remained viable in the CE7.5-treated membranes, while only 1.85 f 1.49 % of necrotic cells were detected in the treated cell population. Fibroblasts treated with the CE7.5 membrane showed a 42 % improvement in wound closure compared to non-treated cells. The anti-inflammatory properties of the electrospun membranes were also investigated. Treatment with the conditioned CE7.5 membrane downregulated Tba1 and tau proteins by 45.1 and 51.055 %, respectively. This study concluded that the newly developed Cinnamomum zeylanicum extract incorporated poly(lactic acid)/gelatin electrospun membranes could be a promising wound dressing material.