Browsing by Author "Koçak, Ayşegül"

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Development of a machine learning-based system to identify disease biomarkers from human gut microbiota
(Abdullah Gül Üniversitesi, Fen Bilimleri Enstitüsü, 2024) Koçak, Ayşegül; AGÜ, Fen Bilimleri Enstitüsü, Elektrik ve Bilgisayar Mühendisliği Ana Bilim Dalı
The human gut microbiota consists of a diverse ecosystem of organisms, encompasses billions of species. Recently developed next-generation sequencing methods have enabled researchers to examine the microbiota in greater detail, leading to new insights into its functions and dysfunctions. This study aims to identify metagenomic biomarkers (Microorganism-Enzyme Pairs) for colorectal cancer (CRC). The tool that we used allows for the analysis of microorganisms and enzymes within the gut microbiota. It achieves this by initially clustering enzymes based on their correlations with species and subsequently utilizing these clustering results to evaluate the ability of groups to differentiate between patient and healthy cohorts. By integrating species and enzymes, it is possible to identify pathogen microorganisms and enzyme clusters, that have the potential to distinguish cases (individuals with CRC) from controls (healthy individuals). The identified enzyme clusters and associated species could potentially act as biomarkers for colorectal cancer (CRC), enabling early diagnosis and more effective treatment. This approach holds promise for further exploration of the gut microbiota and its importance in human health and illness.