Browsing by Author "Härkönen, Juho"

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    The Relationship Between PAPP-A Levels, Maternal Characteristics, Gestational Diabetes and Other Biochemical Markers of the Aneuploidy Screening
    (Institute of Electrical and Electronics Engineers Inc., 2018) Uzut, Ömmu Gülsüm; Kaymakçalan, Hande; Härkönen, Juho; Bakir-Güngör, Burcu
    First trimester aneuploidy screening is routinely used in pregnancy follow-ups. In this screening, free β-hCG and pregnancy-associated plasma protein A (PAPP-A) levels in the blood of the pregnant woman are measured. The aim of this study is to investigate the relationship between PAPP-A levels, maternal characteristics, diabetes, ultrasound measurements of the fetus and other biochemical markers of the aneuploidy screening. In this study, we used the dataset of 12 428 pregnant women, who are followed by some of our researchers at the Prenatal Unit of Yale University Hospital in USA. The correlation of free-β-hCG, PAPP-A and Down syndrome risk with thyroid stimulating hormone (TSH), glucose and hematocrit was analyzed. A statistically significant correlation (p=0.0005) was found between the PAPP-A levels in the group of diabetic pregnants and PAPP-A levels in non-diabetic pregnant group. Detailed studies on the effect of PAPP-A on insulin growth factor could make it possible to use PAPP-A levels to predict gestational diabetes. © 2019 Elsevier B.V., All rights reserved.
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    The Relationship Between TSH Levels, Maternal Characteristics and Racial Group of the Aneuploidy Screening
    (Institute of Electrical and Electronics Engineers Inc., 2022) Soylemez, Ummu Gülsüm; Kaymakçalan, Hande; Härkönen, Juho; Bakir-Güngör, Burcu
    First-trimester maternal screening is a widely used test for detecting fetal aneuploidies and neural tube defects for over two decades. Human chorionic gonadotropin hormone (beta-hCG) and pregnancy-associated plasma protein A (PAPP-A) are two serum biomarkers that are analyzed in this screening. The thyroid hormone is a critical hormone for normal pregnancy and fetal development. During the first half of pregnancy, placental and fetal development depends on the thyroid hormone levels in the mother. Therefore, thyroid abnormalities in the mother can result in unfavorable pregnancy outcomes such as intrauterine growth restriction, miscarriage, hypertensive disorders, premature birth, and an increase in the risk of low IQ in the newborn. In this study, we analyzed the first-trimester screening data collected from 410 pregnant women who were seen at Yale University Hospital Prenatal Unit; and checked for possible correlations of TSH levels with maternal characteristics, racial group PAPP-A MoM levels. © 2022 Elsevier B.V., All rights reserved.