Browsing by Author "Egemen, Ece"

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    PANOGA: a Web Server for Identification of SNP-Targeted Pathways From Genome-Wide Association Study Data
    (Oxford Univ Press, 2014) Bakir-Gungor, Burcu; Egemen, Ece; Sezerman, Osman Ugur
    Genome-wide association studies (GWAS) have revolutionized the search for the variants underlying human complex diseases. However, in a typical GWAS, only a minority of the single-nucleotide polymorphisms (SNPs) with the strongest evidence of association is explained. One possible reason of complex diseases is the alterations in the activity of several biological pathways. Here we present a web server called Pathway and Network-Oriented GWAS Analysis to devise functionally important pathways through the identification of SNP-targeted genes within these pathways. The strength of our methodology stems from its multidimensional perspective, where we combine evidence from the following five resources: (i) genetic association information obtained through GWAS, (ii) SNP functional information, (iii) protein-protein interaction network, (iv) linkage disequilibrium and (v) biochemical pathways.