Browsing by Author "Ceylan, Saniye Aylin"

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3D Biyobaskı Parametrelerinin PCL İskelesinin Basılabilirliği ve Mekanik Davranışı Üzerindeki Etkisi
(Abdullah Gül Üniversitesi / Fen Bilimleri Enstitüsü, 2023) Ceylan, Saniye Aylin; İşoğlu, İsmail Alper; AGÜ, Fen Bilimleri Enstitüsü, Biyomühendislik Ana Bilim Dalı; 01. Abdullah Gül University; 04. Yaşam ve Doğa Bilimleri Fakültesi; 04.01. Biyomühendislik
Polycaprolactone (PCL) is a synthetic polymer that exhibits desirable properties such as biodegradability, tolerable mechanical properties, and biocompatibility for a diverse range of tissue engineering applications. In this study, we analyzed the effects of polymer concentration (10%, 25%, 50% and 75% w/v), solvent effect (dichloromethane, chloroform and acetic acid), and device parameters (pressure, speed, nozzle-surface distance, nozzle gauge, infill density) on printed scaffolds fabricated through 3D Bioprinting. Scanning electron microscopy (SEM) and optical microscopy were used to assess printability, and uniaxial tensile testing was performed to evaluate mechanical behavior. The aim of this study was to investigate the effects of different printing speeds (5 mm/s, 10 mm/s, and 15 mm/s) on the mechanical properties of PCL_DCM and PCL_CF scaffolds. The scaffolds printed at the lowest speed exhibited the highest ultimate tensile strength (UTS) values. Scaffolds printed at 5 mm/s with the highest printing pressure (480 kPa) demonstrated a remarkably high Young's modulus of 39.69 MPa and a UTS value of 6.4 for PCL_DCM, as well as Young's modulus of 26.80 MPa and a UTS value of 6.3 MPa for PCL_CF. Additionally, we investigated the influence of polymer concentrations (50% and 75%) and infill densities (50%, 70%, and 90%). The results showed that increasing the infill density and using a lower concentration (50%) led to improvements in Young's modulus and UTS values for both PCL_DCM and PCL_CF scaffolds. These results highlight the importance of carefully controlling printing parameters to optimize the mechanical properties of the printed scaffolds.
Tuning Mechanical Performance of PCL Scaffolds: Influence of 3D Bioprinting Parameters, Polymer Concentration, and Solvent Selection
(IOP Publishing Ltd, 2025) Ceylan, Saniye Aylin; Baltacioglu, Mehmet Furkan; Bal, Burak; Bayram, Ferdi Caner; Isoglu, Ismail Alper; 02.06. Makine Mühendisliği; 01. Abdullah Gül University; 02. Mühendislik Fakültesi; 04. Yaşam ve Doğa Bilimleri Fakültesi; 04.01. Biyomühendislik
The mechanical performance of three-dimensional (3D) bioprinted scaffolds is susceptible to printing parameters and material formulation. In this study, poly (epsilon-caprolactone) (PCL) scaffolds were fabricated using four different polymer concentrations (10%, 25%, 50%, and 75% w/v) to investigate how these variations, along with process parameters, influence mechanical behavior. Maintaining the structural integrity of bioprinted constructs requires careful optimization of polymer concentration and precise control over parameters such as printing speed, pressure, and infill density. Tensile tests were conducted to evaluate the effects of these variables. Among the tested conditions, a 50% (w/v) concentration allowed for a broader operational window, enabling fabrication across a range of printing speeds and pressures. At a printing speed of 5 mm s-1, PCL-DCM exhibited a Young's modulus of 39.0 MPa, while PCL-CF samples printed at 10 mm s-1 achieved the highest modulus of 32.0 MPa. Notably, when the printing speed was kept constant, applying higher pressures led to an increase in Young's modulus, suggesting that pressure plays a key role in enhancing scaffold stiffness. When comparing the 50% and 75% (w/v) polymer concentrations, the 50% (w/v) formulation stood out by offering both higher elongation and greater stiffness, which makes it particularly suitable for load-bearing applications. These findings provide a quantitative framework for optimizing extrusion-based bioprinting of PCL scaffolds, with implications for customized biomedical implants and regenerative medicine.