Bilgisayar Mühendisliği Bölümü Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.12573/203

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Browsing Bilgisayar Mühendisliği Bölümü Koleksiyonu by Author "0000-0002-0336-4825"

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    Article
    Alzheimer Disease Associated Loci: APOE Single Nucleotide Polymorphisms in Marmara Region
    (MDPI, 2024) Ismail, Aya Badeea; Dundar, Mehmet Sait; Erguzeloglu, Cemre Ornek; Ergoren, Mahmut Cerkez; Alemdar, Adem; Ozemri Sag, Sebnem; Temel, Sehime Gulsun; 0000-0002-0336-4825; AGÜ, Mühendislik Fakültesi, Bilgisayar Mühendisliği Bölümü; Dundar, Mehmet Sait
    Alzheimer’s disease (AD) is a major global health challenge, especially among individuals aged 65 or older. According to population health studies, Turkey has the highest AD prevalence in the Middle East and Europe. To accurately determine the frequencies of common and rare APOE single nucleotide polymorphisms (SNPs) in the Turkish population residing in the Marmara Region, we conducted a retrospective study analyzing APOE variants in 588 individuals referred to the Bursa Uludag University Genetic Diseases Evaluation Center. Molecular genotyping, clinical exome sequencing, bioinformatics analysis, and statistical evaluation were employed to identify APOE polymorphisms and assess their distribution. The study revealed the frequencies of APOE alleles as follows: ε4 at 9.94%, ε2 at 9.18%, and ε3 at 80.68%. The gender-based analysis in our study uncovered a tendency for females to exhibit a higher prevalence of mutant genotypes across various SNPs. The most prevalent haplotype observed was ε3/ε3, while rare APOE SNPs were also identified. These findings align with global observations, underscoring the significance of genetic diversity and gender-specific characteristics in comprehending health disparities and formulating preventive strategies.
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    Article
    Artificial cells: A potentially groundbreaking field of research and therapy
    (Sciendo, 2024) Dundar, Mehmet Sait; Yildirim, A. Baki; Yildirim, Duygu T.; Akalin, Hilal; Dundar, Munis; 0000-0002-0336-4825; AGÜ, Mühendislik Fakültesi, Bilgisayar Mühendisliği Bölümü; Dundar, Mehmet Sait
    Artificial cells are synthetic constructs that mimic the architecture and functions of biological cells. Artificial cells are designed to replicate the fundamental principles of biological systems while also have the ability to exhibit novel features and functionalities that have not been achieved before. Mainly, Artificial cells are made up of a basic structure like a cell membrane, nucleus, cytoplasm and cellular organelles. Nanotechnology has been used to make substances that possess accurate performance in these structures. There are many roles that artificial cells can play such as drug delivery, bio-sensors, medical applications and energy storage. An additional prominent facet of this technology is interaction with biological systems. The possibility of synthetic cells being compatible with living organisms opens up the potential for interfering with specific biological activities. This element is one of the key areas of research in medicine, aimed at developing novel therapies and comprehending life processes. Nevertheless, artificial cell technology is not exempt from ethical and safety concerns. The interplay between these structures and biological systems may give rise to questions regarding their controllability and safety. Hence, the pursuit of artificial cell research seeks to reconcile ethical and safety concerns with the potential advantages of this technology