Khalily, Mohammad ArefUsta, HakanOzdemir, MehmetBakan, GokhanDikecoglu, F. BegumEdwards-Gayle, CharlotteGuler, Mustafa O.2025-09-252025-09-2520182040-33642040-3372https://doi.org/10.1039/c8nr01604fhttps://hdl.handle.net/20.500.12573/4773Usta, Hakan/0000-0002-0618-1979; Guler, Mustafa O./0000-0003-1168-202X; Hamley, Ian/0000-0002-4549-0926; Edwards-Gayle, Charlotte/0000-0001-7757-107Xpi-Conjugated small molecules based on a [1]benzothieno[3,2-b]benzothiophene (BTBT) unit are of great research interest in the development of solution-processable semiconducting materials owing to their excellent charge-transport characteristics. However, the BTBT -core has yet to be demonstrated in the form of electro-active one-dimensional (1D) nanowires that are self-assembled in aqueous media for potential use in bioelectronics and tissue engineering. Here we report the design, synthesis, and self-assembly of benzothienobenzothiophene (BTBT)-peptide conjugates, the BTBT-peptide (BTBT-C-3-COHN-Ahx-VVAGKK-Am) and the C-8-BTBT-peptide (C-8-BTBT-C-3-COHN-Ahx-VVAGKK-Am), as -sheet forming amphiphilic molecules, which self-assemble into highly uniform nanofibers in water with diameters of 11-13(+/- 1) nm and micron-size lengths. Spectroscopic characterization studies demonstrate the J-type - interactions among the BTBT molecules within the hydrophobic core of the self-assembled nanofibers yielding an electrical conductivity as high as 6.0 x 10(-6) S cm(-1). The BTBT -core is demonstrated, for the first time, in the formation of self-assembled peptide 1D nanostructures in aqueous media for potential use in tissue engineering, bioelectronics and (opto)electronics. The conductivity achieved here is one of the highest reported to date in a non-doped state.eninfo:eu-repo/semantics/openAccessArticle10.1039/c8nr01604f2-s2.0-85047940195