Ayhan, Mehmet MenafOzcan, EmrahAlkan, FahriCetin, MetinUn, IlkerBardelang, DavidCosut, Bonyemin2022-03-042022-03-0420212633-5409https //doi.org/10.1039/d1ma00931ahttps://hdl.handle.net/20.500.12573/1233Organic luminescent compounds with high emission properties play a crucial role in fluorescence labelling and optoelectronic devices. In this work, we prepared three water soluble BODIPY derivatives (B-4, B-5, and B-6) which are weakly fluorescent due to non-radiative relaxation pathways (charge transfer: CT or heavy atom effect). However, CB[7] significantly improves BODIPY fluorescence by similar to 10 fold for B-4, and by similar to 3 fold for B-5. The (TD)DFT analyses suggest that for B-4 and B-5, the CT state is blue-shifted as a result of the external binding of CB[7] near the pyridinium groups. This effect favoured a radiative decay through a locally-excited (LE) pi ->pi* transition state of BODIPYs resulting in a CB[7]-induced emission increase in solution (and in the solid state), without compromising singlet-to-triplet intersystem crossing (ISC). The improved emission of the BODIPY center dot CB[7] complexes was used for the fluorescence imaging of U87 cells illustrating the relevance of this approach. These results suggest that BODIPY center dot CB[7] complexes could be used as theragnostic agents by combining fluorescence imaging and treatment by photodynamic therapy.enginfo:eu-repo/semantics/openAccessSOLID-STATEENHANCED FLUORESCENCEDYESPHOTOSENSITIZERSDERIVATIVESarticleVolume 3 Issue 1 Page 547-553