Alapan, YunusIcoz, KutayGurkan, Umut A.2025-09-252025-09-2520150734-97501873-1899https://doi.org/10.1016/j.biotechadv.2015.09.001https://hdl.handle.net/20.500.12573/4192Alapan, Yunus/0000-0003-3064-7342; Gurkan, Umut A./0000-0002-0331-9960; Icoz, Kutay/0000-0002-0947-6166Understanding how biomolecules, proteins and cells interact with their surroundings and other biological entities has become the fundamental design criterion for most biomedical micro- and nanodevices. Advances in biology, medicine, and nanofabrication technologies complement each other and allow us to engineer new tools based on biomolecules utilized as probes. Engineered micro/nanosystems and biomolecules in nature have remarkably robust compatibility in terms of function, size, and physical properties. This article presents the state of the art in micro- and nanoscale devices designed and fabricated with biomolecular probes as their vital constituents. General design and fabrication concepts are presented and three major platform technologies are highlighted: microcantilevers, micro/nanopillars, and microfluidics. Overview of each technology, typical fabrication details, and application areas are presented by emphasizing significant achievements, current challenges, and future opportunities. (C) 2015 Elsevier Inc. All rights reserved.eninfo:eu-repo/semantics/openAccessBiosensingMicro/NanofabricationMicrocantileversMicro/NanopillarsMicrofluidic ChannelsSurface FunctionalizationCell AdhesionBiomoleculesCell IsolationPoint-of-Care DiagnosisArticle10.1016/j.biotechadv.2015.09.0012-s2.0-84950136858